生物标志物 生物标志物
Kay Jann1, Ru Zhang1, Jared Brown2
1Mark and Mary Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, CA, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
功能性MRI (fMRI) 复杂性,通过多尺度样本 (MSE) 测量,可以检测早期的认知衰退. 在特定的大脑区域的改变fMRI复杂性表明阿尔茨海默病的进展,表明其早期诊断的潜力.
科学领域:
- 神经科学是一个神经科学.
- 信息理论 信息理论
- 生物统计学 生物统计学
背景情况:
- 非线性统计技术,特别是基于的fMRI复杂性,对于研究神经认知衰老和神经退行性疾病至关重要.
- 减少fMRI复杂性与信息处理受损和阿尔茨海默病进展相关.
- 这项研究探讨了fMRI复杂性作为认知衰退的早期标志物.
研究的目的:
- 使用多尺度样本 (MSE) 作为认知衰退的早期指标,研究fMRI复杂性.
- 区分具有稳定的认知状态的参与者和疾病进展阶段的参与者.
- 评估MSE在阿尔茨海默病早期诊断和预后监测方面的潜力.
主要方法:
- 分析了参与者的fMRI数据,分为正常认知 (NC),稳定的轻度认知障碍 (MCI),NC到MCI转换器 (NC2MCI) 和MCI到阿尔茨海默病转换器 (MCI2AD).
- 使用CONN工具箱预处理的fMRI数据,并用四个尺度计算MSE,m=2和r=0.3.3.
- 采用了一般化的线性模型和Dunnett的测试进行群组比较,调整为共变量.
主要成果:
- 两组之间没有发现全球灰色物质MSE的显著差异.
- 在MSE中观察到的统计学上显著的差异是中额头 (MFG),上额头 (SFG),侧叶 (LTL) 和中叶 (MTL).
- 具体来说,MCI2AD和NC2MCI组显示MFG中MSE减少,MCI2AD组显示LTL中MSE减少.
结论:
- 在转换到更严重的疾病阶段的个体中,fMRI复杂性 (MSE) 发生了显著的变化,但在稳定的群体中没有.
- 这些发现凸显了fMRI复杂性对与疾病进展相关的早期症状前变化的敏感性.
- 作为早期阿尔茨海默病诊断,预后监测和个性化护理的工具,MSE显示出希望.
相关概念视频
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
749
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
749
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
516
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
516