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相关概念视频

Infection01:20

Infection

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When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
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Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

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The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
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Cystic Fibrosis: Pathogenesis01:23

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Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
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Stages of Infection01:26

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Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
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The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
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基础科学和病原发生学

D Luke Fischer1, Salvatore Spina2, Bruce L Miller1

  • 1Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
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PubMed
概括
此摘要是机器生成的。

与TDP-43 (FTLD-TDP) 类型A和边缘主导,与年龄相关的TDP-43脑病变神经病理变化 (LATE-NC) 的前叶退化具有共同的组织学特征,但是不同的. 临床,遗传和区域差异支持FTLD-TDP类型A和LATE-NC的单独诊断术语.

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科学领域:

  • 神经科学是一个神经科学.
  • 神经病理学神经病理学
  • 遗传学 遗传学 是一个

背景情况:

  • 带有TDP-43 (FTLD-TDP) 的前叶退化和边缘主导的,与年龄相关的TDP-43脑病变神经病理变化 (LATE-NC) 呈现重叠的组织学特征.
  • 这种重叠引发了关于这些情况是否代表疾病谱的辩论.

研究的目的:

  • 调查FTLD-TDP A型和LATE-NC是否是不同的实体或疾病频谱的一部分.
  • 为了比较FTLD-TDP A型和LATE-NC.的临床,遗传和神经病理特征.

主要方法:

  • 来自148个FTLD-TDP病例 (类型AD-D,无法分类) 和42个LATE-NC病例的人口,临床和遗传数据的比较分析.
  • 与LATE-NC相比,专注于TDP-Type A和Type U病例,有或没有同时存在的阿尔茨海默氏症神经病理变化 (ADNC),与LATE-NC相比.
  • 通过四名评分员对中前额回形进行盲目评估,以评估A型和LATE-NC第3阶段之间的诊断差异.

主要成果:

  • 与LATE-NC.相比,FTLD-TDP A型病例呈现出较早的症状发作,死亡年龄和较短的疾病持续时间.
  • 晚期NC仅在零星病例中被诊断出来,而FTLD-TDP类型A通常是遗传的.
  • 甲型FTLD-TDP与前性痴呆综合征有关,而LATE-NC通常与记忆障碍 (阿尔茨海默病相关) 综合征相关.

结论:

  • 尽管有共同的组织学特征,但FTLD-TDP型A和LATE-NC是不同的疾病.
  • 临床表现,遗传关联和区域病理学的差异支持将它们归类为独立实体.
  • 保持FTLD-TDP类型A和LATE-NC的独特诊断术语是适当的.