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临床表现 临床表现

David López-Martos1,2, Raffaele Cacciaglia1,3,4, Marc Suárez-Calvet1,5,6

  • 1Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.

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概括

无意识,或缺乏对障碍的意识,与阿尔茨海默病 (AD) 生物标志物和大脑变化有关,甚至在轻度认知障碍 (MCI) 发生之前. 早期发现无意识症对于患有AD痴呆风险的个体的及时干预至关重要.

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科学领域:

  • 神经科学是一个神经科学.
  • 神经学 神经学
  • 生物标志物 生物标志物

背景情况:

  • 无意识 (缺乏对障碍的意识) 在阿尔茨海默病 (AD) 中很常见,但在轻度认知障碍 (MCI) 标准中未被认可.
  • 相反,使用主观认知衰退 (SCD),但它不特定于AD,可能不在MCI中.
  • 安索格诺西亚的神经病理基础及其在阿尔茨海默病早期阶段的作用仍然不清楚.

研究的目的:

  • 研究多式AD生物标志物与元认知变化之间的纵向关系.
  • 为了检查这些协会在认知无障碍 (CU) 个体有风险的AD痴呆症.

主要方法:

  • 研究了331名具有早期AD生物标志物概况的CU参与者.
  • 使用了基线CSF和血生物标志物,3年纵向MRI和神经心理测试.
  • 超记忆轨迹被计算为客观和主观认知表现之间的差异.

主要成果:

  • 超记忆的下降与较低的CSF Aβ42/40和较高的CSF p-tau181/Aβ42.2相关.
  • 血p-tau217和血GFAP也与元记忆衰退有关.
  • 超级记忆的下降与前额皮质,胰岛和其它大脑区域的灰质体积增加有关.

结论:

  • 在MCI前的阶段,Anosognosia轨迹与AD病理生理学和大脑结构变化有关.
  • 早期发现无意识症至关重要,因为目前的标准可能会忽视它.
  • 识别有风险的个体对于实施AD的客观诊断和预防策略至关重要.