临床表现 临床表现
Rachel W Maina1,2, Wambui Karanja1, Chinedu Udeh-Momoh3,4
1Brain and Mind Institute, Aga Khan University, Nairobi, Nairobi, Kenya.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
适用于肯尼亚成年人的认知测试显示构造有效性,但语义流性需要改进这个多语言人口. 进一步验证认知评估工具对于跨文化使用至关重要.
科学领域:
- 神经科学是一个神经科学.
- 心理学 心理学 心理学
- 认知科学 认知科学
背景情况:
- 认知评估工具的跨文化适应和心理测定验证对于低收入和中等收入国家 (LMICs) 的公平使用至关重要.
- 在高收入国家 (HIC) 开发的认知评估工具需要验证才能在多样化的人口中使用.
- 这项研究解决了在LMICs中对文化相关认知评估的需求.
研究的目的:
- 为了评估多域,多模式认知测试电池的因子结构,在认知不受损的 (CU) 多语种肯尼亚成年人.
- 为了确定测试电池是否符合全球公认的神经心理学领域.
- 评估纸/笔和数字认知测试的心理测量特性.
主要方法:
- 向两个独立的肯尼亚CU成年人样本 (N=135和N=218) 进行了神经心理测试.
- 使用探索性因素分析 (EFA) 和确认性因素分析 (CFA) 来检查因子结构.
- 包括已建立的测试 (NIH HCAP) 和基于平板电脑的新型评估 (基于平板电脑的认知评估工具 (TabCAT)) 的子测试分数.
主要成果:
- EFA揭示了一个三因素结构,解释了62.6%的差异,主要代表了情节性记忆和执行功能/注意力.
- 插曲性记忆子测试对两个不同的因素进行了强烈加载.
- 基于平板电脑的认知评估工具 (TabCAT) 测量了与注意力和执行功能一起的第三个因素,而语义流性显示出较弱的负载.
结论:
- 这些发现支持肯尼亚成年人多域认知测试电池的构造有效性.
- 语义流度的低负载表明需要修改,以更好地捕捉这个多语言人口中的语言领域.
- 需要进一步的研究来完善认知评估工具,以适应不同的语言和文化背景.
相关概念视频
Chronic Kidney Disease II: Clinical Manifestations
520
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
520
Coronary Artery Disease III: Clinical Manifestations
299
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
299
Endocarditis II: Clinical Features of Infective Endocarditis
364
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
364
Heart Failure III: Clinical Manifestations
436
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
436
Gastroesophageal Reflux Disease II: Clinical Features and Management
652
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
652
Hypertension III: Clinical Manifestations and Diagnostic Studies
437
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
437


