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临床表现 临床表现

Paul Maruff1

  • 1University of Melbourne, Melbourne, VIC, Australia.

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概括
此摘要是机器生成的。

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科学领域:

  • 神经科学是一个神经科学.
  • 认知心理学 认知心理学
  • 临床试验 临床试验

背景情况:

  • 认知是临床前阿尔茨海默病 (AD) 临床试验中的关键疗效指标,通过神经心理测试进行评估.
  • 了解临床前阿尔茨海默病患者如何看待这些认知测试至关重要,但仍未得到充分探索.

研究的目的:

  • 探索在患有临床前AD的个体中特定的神经心理测试的主观经验和感知认知需求.
  • 调查参与者对国际购物清单测试 (ISLT),连续配对关联学习测试 (CPAL) 和国际数字符号替换测试-药物版本 (IDSSTm) 测量的认知构造的理解.

主要方法:

  • 采用概念诱导 (CE) 方法,对30名具有异常粉样蛋白水平的认知正常成年人进行了研究.
  • 参与者完成了ISLT,CPAL和IDSSTm的实践版本,同时反思所涉及的思维.
  • 测试后的采访引发了参与者对参与的认知过程的描述.

主要成果:

  • 对于ISLT,参与者经常使用诸如"记忆"",记住"和"回忆"等术语.
  • CPAL的反应集中在"学习"",记忆"和"解决"上.
  • IDSSTm主要被描述为"匹配"和"模式匹配".

结论:

  • 临床前AD患者理解学习和记忆测试 (ISLT,CPAL) 的认知性质,尽管术语有所不同.
  • IDSSTm主要被认为是匹配和组织的任务.
  • 这种对主观认知经验的理解可以改进AD药物试验中临床意义的解释.