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相关概念视频

Infection01:20

Infection

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When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
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Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

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The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
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Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

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Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
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Pneumonia II: Pathophysiology01:29

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The pathophysiology of pneumonia involves the following steps:
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Stages of Infection01:26

Stages of Infection

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Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
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Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

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The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
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Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
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Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

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基础科学和病原发生学

Jo Scanlan1, Trisha M Zintel1, Zoë Leanza1

  • 1Sage Bionetworks, Seattle, WA, USA.

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概括
此摘要是机器生成的。

阿尔茨海默病知识门户网站为研究人员提供了广泛的阿尔茨海默病 (AD) 数据和工具,促进发现. 它不断增长的存储库和用户参与强调了它在推动AD研究和使数据重复使用方面的关键作用.

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科学领域:

  • 神经科学是一个神经科学.
  • 基因组学就是基因组学.
  • 数据科学数据科学数据科学

背景情况:

  • AD知识门户是国家老龄研究所 (NIA) 赞助的资源.
  • 它提供了阿尔茨海默氏症 (AD) 数据和研究工具.

研究的目的:

  • 提供一个集中平台,共享和访问AD研究数据.
  • 促进数据的再利用,并使阿尔茨海默病研究中的新发现成为可能.

主要方法:

  • 使用Synapse安全数据共享平台和一个用户友好的门户网站.
  • 托管各种数据类型,包括下一代测序,成像和行为数据.
  • 与基于云的分析平台集成,如CAVATICA和Terra,以提高数据可访问性.

主要成果:

  • 托管来自14个NIH资助的研究项目和97个赠款的数据,包括来自11000多个人的800TB数据.
  • 具有~290TB的多式单细胞奥米克数据,实验模型和药物向证据.
  • 自2022年1月以来,超过6000名用户下载了超过12.57PB的数据,下载量同比大幅增加.
  • 门户数据被引用在1000多个出版物中,其中>50%代表二次数据重复使用.

结论:

  • 阿尔茨海默病知识门户网站仍然是一个至关重要的资源,使阿尔茨海默病研究中的新发现成为可能.
  • 未来的更新包括与AD Workbench,NACC,NIAGADS,LONI的互操作性,以及空间转录学等新数据类型.