生物标志物 生物标志物
Ting-Wen Chu1,2,3, Yi-Ting Hsieh4, Jen-Ming Chiou5,6
1Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
视网膜生物标志物,如RNFL和GC-IPL厚度显示复杂的联系与认知功能随着时间的推移,受睡眠质量和白天嗜睡的影响. 这些眼睛和睡眠评估可能会改善认知健康预测.
科学领域:
- 眼科和神经病学 眼科和神经病学
- 老年流行病学 老年流行病学
- 生物标志物研究 生物标志物研究
背景情况:
- 临床前痴呆症的早期发现至关重要.
- 视网膜生物标志物,包括视网膜神经纤维层 (RNFL) 和质细胞内状层 (GC-IPL) 厚度,正在研究它们在诊断认知衰退方面的潜力.
- 检查视网膜生物标志物,睡眠模式和老年人认知功能之间的相互作用的纵向研究是有限的.
研究的目的:
- 探索视网膜生物标志物 (RNFL和GC-IPL厚度) 和睡眠模式 (睡眠质量和白天嗜睡) 与非痴呆老年人的认知功能之间的纵向关联.
- 研究视网膜和睡眠评估在预测认知健康轨迹方面的潜力.
主要方法:
- 一项为期四年的前性队列研究,涉及257名非痴呆症老年人.
- 认知功能使用蒙特利尔认知评估-台湾版 (MoCA-T) 和神经心理测试进行评估.
- 通过光学连贯断层扫描 (OCT) 进行视网膜成像,并使用匹兹堡睡眠质量指数 (PSQI) 和爱普沃思睡眠度量表 (ESS) 评估睡眠模式.
- 用于分析关联的多层模型,对共变量进行调整.
主要成果:
- 增加基线RNFL和GC-IPL厚度最初与较差的全球认知有关,但随着时间的推移显示出保护作用.
- 基线GC-IPL厚度与注意力较差相关,但纵向显示对记忆和注意力有保护作用.
- 在睡眠质量和GC-IPL厚度之间发现了对全球认知和注意力的显著相互作用.
- 对于全球认知和记忆,在过度白天嗜睡和GC-IPL厚度之间也观察到显著的相互作用.
结论:
- 视网膜生物标志物表现出与认知功能的非线性关联.
- 视网膜生物标志物和认知功能之间的关系受到睡眠质量和白天嗜睡的相互作用的显著影响.
- 整合视网膜生物标志物和睡眠模式评估可能会提高对认知健康结果的预测.
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