临床表现 临床表现
Soichiro Shimizu1, Shoya Inagawa1, Ryo Yamamoto2
1Tokyo Medical University, Shinjuku-ku, Tokyo, Japan.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
伦博雷克桑 (Lemborexant) 没有改善Lewy体痴呆症 (DLB) 患者的睡眠质量或认知功能. 然而,它没有恶化认知功能,睡眠开始后醒来 (WASO) 或REM睡眠行为障碍 (RBD).
科学领域:
- 神经学 神经学
- 睡眠医学 睡眠医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 由于对梦和REM睡眠行为障碍 (RBD) 的担忧,素受体对抗剂在Lewy体痴呆症 (DLB) 中未得到充分利用.
- 在DLB患者中研究Lemborexant的安全性和有效性,这是一种素受体对抗剂,对于临床实践至关重要.
研究的目的:
- 评估Lemborexant对DLB患者睡眠概况和认知功能的影响.
- 为了确定Lemborexant是否会加剧梦,RBD或DLB的认知衰退.
主要方法:
- 13名可能患有DLB的患者接受了Lemborexant (5mg) 治疗失眠.
- 在治疗前和后的7天内,使用动图来评估睡眠变量 (TST,睡眠效率,WASO,觉醒).
- 认知功能使用迷你精神状态检查 (MMSE) 进行评估;睡眠障碍严重程度使用JESS,AIS-J和RBDSQ-J进行评估.
主要成果:
- 伦博雷克桑对DLB患者的睡眠质量没有显著改善.
- 在Lemborexant给药后,没有观察到认知功能 (MMSE得分) 的显著差异.
- 动图学数据显示,睡眠开始后 (WASO) 觉醒或总睡眠时间没有恶化.
结论:
- 兰博雷克桑可以在DLB患者中使用,而不会恶化认知功能或睡眠障碍.
- 该研究表明,Lemborexant不会在DLB患者中加剧REM睡眠行为障碍 (RBD) 症状.
- 这些发现支持谨慎使用Lemborexant治疗DLB失眠,等待进一步研究.
相关概念视频
Chronic Kidney Disease II: Clinical Manifestations
520
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
520
Coronary Artery Disease III: Clinical Manifestations
299
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
299
Endocarditis II: Clinical Features of Infective Endocarditis
364
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
364
Heart Failure III: Clinical Manifestations
436
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
436
Gastroesophageal Reflux Disease II: Clinical Features and Management
652
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
652
Hypertension III: Clinical Manifestations and Diagnostic Studies
437
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
437


