生物标志物 生物标志物
Farzaneh Rahmani1, Joseph E Ippolito2, Jingxia Liu3
1Mallinckrodt Institute of Radiology, St. Louis, MO, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
较高的头部脂肪增加了阿尔茨海默氏症 (AD) 风险,而肌体积可能对男性有保护作用. 头部组成指标可以预测痴呆症转化和大脑缩.
科学领域:
- 神经学 神经学
- 放射学 放射学是一门学科.
- 老年学是一门学科.
背景情况:
- 内脏和部脂肪,以及肉,与阿尔茨海默病 (AD) 风险增加有关.
- 计算机断层扫描 (CT) 扫描衍生的脂肪和脂肪量化可以帮助估计AD预测概率.
- 调查头部CT组合指标为AD风险提供了洞察力.
研究的目的:
- 检查头部CT组合指标与患阿尔茨海默病 (AD) 的风险之间的关系.
- 为了确定头部和部组成是否可以预测从正常认知转换到早期痴呆症.
- 探索AD风险人群中头部组成指标和大脑缩之间的相关性.
主要方法:
- 对具有正常认知和阴性粉样蛋白PET扫描的参与者进行了痴呆症转换的跟踪.
- 用数据分析便利套件 (DAFS) 分析CT扫描以确定组合指标.
- 使用FreeSurfer进行了脑MRI体积分析;进行了生存和相关性分析.
主要成果:
- 头部肌肉间脂肪组织较高与痴呆症转化风险增加3倍有关.
- 男性的肌体积增加,但女性没有,显示出对痴呆症转换的保护作用.
- 肌体积与前皮和内皮层体积直接相关,即使经过对内体积进行调整.
结论:
- 来自CT扫描的头组成指标可以预测未来的痴呆风险.
- 这些指标与大脑缩相关,这表明基于CT的AD自动查有潜力.
- 在肌肉体积和痴呆风险之间的关系中观察到性别特异性差异.
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