生物标志物 生物标志物
Soheil Mohammadi1, Farzaneh Rahmani2, Mahsa Dolatshahi1
1Mallinckrodt Institute of Radiology, Washington University in St. Louis, St. Louis, MO, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
肥胖与较低的阿尔茨海默病 (AD) 血液生物标志物水平有关,但预测了更快的粉样蛋白积累和p-tau217.17的变化. 这些发现影响了对肥胖个体的AD生物标志物的解释.
科学领域:
- 神经退行性疾病的神经退行性疾病
- 生物标志物研究的研究.
- 肥胖和代谢健康问题
背景情况:
- 肥胖是已知的阿尔茨海默病 (AD) 风险因素之一.
- 肥胖对AD血液生物标志物 (BBM) 轨迹的影响尚不清楚.
- 这项研究探讨了肥胖如何影响血生物标志物和AD中的粉样蛋白负担的变化.
研究的目的:
- 为了研究肥胖和阿尔茨海默病 (AD) 进展之间的关系.
- 分析肥胖对血液生物标志物 (BBM) 随时间变化的影响.
- 了解肥胖如何影响AD中的粉样蛋白负荷积累.
主要方法:
- 使用来自阿尔茨海默病神经成像计划 (ADNI) 的血样本.
- 使用 (11)C-匹兹堡化合物-B正子发射断层扫描 (PET) 评估了全球粉样蛋白负担.
- 采用斯皮尔曼的部分相关性和线性混合效应回归模型来分析身体质量指数 (BMI),BBMs和时间之间的关联.
主要成果:
- 更高的BMI与较低的基线粉样蛋白负担相关,p-tau217,%p-tau217,GFAP和NFL.
- 与非肥胖个体相比,肥胖的参与者显示粉样蛋白负担 (PET) 和血p-tau217/%p-tau217的增加更快.
- 肥胖与NfL或GFAP的变化率没有一致的关联.
结论:
- 肥胖与较低的基线AD血液生物标志物水平相关,但加速了粉样蛋白积累和p-tau217变化.
- 这些发现为解释肥胖个体的ADBBM提供了关键的背景.
- 这项研究提供了关于肥胖对AD病理进展的影响的见解.
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