生物标志物 生物标志物
Fei Wu1,2, Ali Dirani3, Monica Lavoie4,5
1Clinique Interdisciplinaire de Mémoire, CHU de Québec-Université Laval, Québec, QC, Canada.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
洛戈佩尼克变体初级渐进性阿法西亚 (lvPPA) 患者表现出更薄的视网膜神经纤维层和减少的状无血管区循环. 这些光学连贯性断层扫描 (OCT) 和OCT血管学 (OCT-A) 发现表明lvPPA的早期诊断生物标志物的潜力.
科学领域:
- 神经科学是一个神经科学.
- 眼科医生 眼科 眼科
- 放射学 放射学是一门学科.
背景情况:
- 主要渐进性失言症 (lvPPA) 是一种神经退行性语言障碍.
- 氨基粉症是86%的lvPPA病例的基础,类似于阿尔茨海默病 (AD).
- 光学连贯断层扫描 (OCT) 和OCT血管学 (OCT-A) 是在AD中探索的非侵入性视网膜生物标志物,但尚未在lvPPA中探索.
研究的目的:
- 为了比较lvPPA患者的视网膜发现和使用OCT和OCT-A的健康对照.
- 研究OCT和OCT-A作为lvPPA的非侵入性生物标志物的潜力.
主要方法:
- 一项横截面研究包括lvPPA患者和年龄/性别匹配的健康对照.
- 眼科评估排除了具有先前神经或眼睛疾病的参与者.
- 进行了OCT/OCT-A成像; lvPPA患者还接受了腰部穿刺和临床痴呆评分 (CDR) 评估.
主要成果:
- 分析了10名lvPPA患者 (所有患者都患有粉样蛋白病变) 和11名对照患者.
- 与对照组相比,lvPPA患者表现出明显较薄的时间视网膜神经纤维层 (RNFL) (63.1 ± 3.3μm与75.6 ± 3.2μm相比,p=0.013).
- lvPPA患者显示出明显较低的状血管区 (FAZ) 圆度 (0.69 ± 0.02 与 0.77 ± 0.02 相比,p=0.002).
结论:
- 在lvPPA中减少RNFL厚度可能表明由于粉样蛋白积累或逆行性退行导致的神经元退化.
- 在lvPPA中FAZ循环的减少可能表明早期的粉样蛋白诱导的血管变化.
- 超越国外地区和超越国外地区-A显示为有价值的非侵入性生物标志物,有望提高lvPPA的早期诊断.
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