生物标志物 生物标志物
Elise Saul1, Jade Lasserve1, Léa Chauveau1
1Normandie Univ, UNICAEN, INSERM, U1237, PhIND "Physiopathology and Imaging of Neurological Disorders", NeuroPresage Team, GIP Cyceron, Caen, France.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
阿尔茨海默病 (AD) 和衰老影响中叶 (MTL) 网络. 粉样蛋白-β (Aβ) 影响白质完整性,影响前 (AT) 功能连接,特别是在Aβ水平高的情况下.
科学领域:
- 神经成像是一种神经成像.
- 神经退行性疾病 神经退行性疾病
- 大脑的连接性 大脑的连接性
背景情况:
- 中间叶 (MTL) 网络,前 (AT) 和后 (PM),在衰老和阿尔茨海默病 (AD) 中受损.
- 之前的研究表明,在AD中存在AT超连接性,在衰老中存在PM低连接性,但结构连接性仍然不清楚.
- 了解这些网络的结构性基础对于阐明它们在认知衰退中的作用至关重要.
研究的目的:
- 为了识别支持AT和PM网络的白质纤维.
- 为了研究粉样β (Aβ) 积累对这些白质纤维的影响.
- 检查白质纤维完整性和这些网络中的功能连接性之间的关系.
主要方法:
- 在89名健康的老年人中,AT和PM网络的结构和功能连接性使用扩散皮质图像 (DKI) 和静止状态fMRI进行了评估.
- 周围神经和副海马皮层作为种子区域用于相关性和曲谱学分析.
- 使用Florbetapir-PET成像量化了粉样β (Aβ) 沉积量.
主要成果:
- 鉴定出海马环带和下纵向囊是AT和PM网络的关键组成部分.
- 在Aβ负担和白质纤维完整性之间观察到一个反转的U形关系.
- 高Aβ水平与AT结构和功能连接之间的负相关性有关,而低Aβ水平显示出正相关性.
结论:
- 粉样蛋白-β (Aβ) 显著影响中叶 (MTL) 的结构连接.
- Aβ积累与前 (AT) 网络内的结构和功能连接的改变有关.
- 这些发现为Aβ,结构完整性和老化大脑中的功能连接之间的复杂相互作用提供了新的见解.
相关概念视频
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
749
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
749
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
516
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
516