生物标志物 生物标志物
Gabrielle Walach1,2, Kody Kennedy1, Mikaela Dimick1
1Centre for Addiction and Mental Health, Toronto, ON, Canada.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
患有双相情感障碍 (BD) 的年轻人表现出与阿尔茨海默病 (AD) 遗传风险相关的大脑结构变化. 与健康对照人群相比,较高的AD多基因风险得分 (PRS) 与BD患者的大脑体积减少相关.
科学领域:
- 神经成像是一种神经成像.
- 遗传学 是一个遗传学.
- 精神病学是一个精神病学.
背景情况:
- 双极性障碍 (BD) 增加了阿尔茨海默病 (AD) 的风险.
- 早期的阿尔茨海默病的发病因子对于理解疾病的发展至关重要.
- 在年轻人中评估AD遗传风险可能会揭示神经结构易感性.
研究的目的:
- 研究AD多基因风险评分 (PRS) 与青少年和年轻人的大脑结构之间的关联.
- 检查AD-PRS如何与诊断 (BD与健康对照) 相互作用以影响大脑结构.
- 在这些关联中探索潜在的性别差异.
主要方法:
- 来自112名年龄在13-20岁的青少年 (67名BD,45名HC) 的T1加权MRI数据.
- 使用PRS-CS-auto进行AD-PRS计算.
- 一般线性模型和顶点分析评估了AD-PRS对区域大脑结构的影响,控制共变量.
主要成果:
- 在整个样本中,较高的AD-PRS与较低的上旋体积相关.
- 在BD年轻人中,较高的AD-PRS显示出与减少的区域大脑结构 (例如,上性,前,额头和部区域) 的较强关联.
- 性别分层分析揭示了不同的模式:女性的上顶顶叶片指标减少,而男性的上边缘和正面中间前额回路指标增加.
结论:
- 升高的AD-PRS与患有BD的年轻人的大脑结构减弱有关.
- 研究结果表明,AD遗传风险对BD中大脑发育的潜在性别特异性影响.
- 需要进行纵向研究来跟踪AD-PRS和大脑结构关联的发育变化.
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