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轻度行为障碍与冷漠 (MBI-冷漠) 与早期阿尔茨海默病 (AD) 区域的大脑缩有关. 这表明MBI-冷漠可能表明早期的AD变化,甚至在显著的认知能力下降之前.

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科学领域:

  • 神经科学是一个神经科学.
  • 老年学是一门学科.
  • 神经学 神经学

背景情况:

  • 轻度行为障碍 (MBI) 是一种痴呆前综合征,其特征是行为变化和认知能力下降的风险标志物.
  • 假设MBI的冷漠领域涉及大脑变化,但其与痴呆症冷漠的关系尚不清楚.

研究的目的:

  • 为了研究MBI-无情和那些没有神经精神症状 (没有NPS) 的个体之间的体积大脑差异.
  • 为了确定MBI冷漠是否与早期阿尔茨海默病 (AD) 中受影响的大脑区域有关.

主要方法:

  • 来自国家阿尔茨海默氏症协调中心 (NACC) 的446名参与者的横截面研究.
  • 使用线性回归,对MBI-冷漠 (n=59) 和没有NPS (n=387) 的组比较.
  • 对区域大脑体积和皮质厚度的分析,包括与AD相关的和与冷漠相关的区域,经过对共变量进行调整.

主要成果:

  • MBI-无情与较低的平均AD复合皮质厚度和总体积显著相关.
  • 患有MBI-无情的个体在背侧前额皮层 (dlPFC) 的厚度降低,轨道前额皮层 (OFC) 和dlPFC的体积降低.

结论:

  • MBI-无动于衷与大脑区域的缩有关,这些区域通常在AD早期受到影响.
  • 这些发现表明,MBI无动于衷可能反映了早期AD相关的大脑变化在认知正常和轻度认知障碍阶段.
  • 与冷漠相关的大脑区域可能会在AD进展的晚期受到影响.