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使用波士顿神经认知健康远程认知评估 (BRANCH) 进行的远程认知测试显示,用于检测早期阿尔茨海默氏症 (AD) 变化具有前途. 较低的BRANCH分数与较高的p-tau217水平相关,表明可扩展的AD风险检测潜力.

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科学领域:

  • 神经科学是一个神经科学.
  • 生物标志物 生物标志物
  • 认知评估 认知评估

背景情况:

  • 早期发现阿尔茨海默病 (AD) 对于有效的二次预防策略至关重要.
  • 结合远程认知评估和血液生物标志物的创新方法为识别早期AD相关认知变化提供了可扩展的解决方案.
  • 波士顿神经认知健康远程认知评估 (BRANCH) 评估其检测与早期AD病理生理学相关的认知变化的能力,使用血p-tau217作为生物标志物.

研究的目的:

  • 调查多日BRANCH认知评估是否捕捉了与早期AD病理生理学相关的认知变化.
  • 确定BRANCH认知评估得分与认知不受损的老年人血p-tau217水平之间的关联.
  • 为了比较BRANCH的灵敏度与标准认知复合物 (PACC-5) 在检测早期AD相关变化的过程中.

主要方法:

  • 254名没有认知障碍的老年人完成了在个人设备上进行的为期几天的BRANCH评估,包括关联记忆和处理速度测试.
  • 每次测试计算了多天学习曲线 (MDLC) 评分,并将其平均为分支复合MDLC.
  • 线性回归模型评估了日志转换血p-tau217水平与BRANCH复合MDLC得分之间的关联,并对相关共变量进行了调整.

主要成果:

  • 较低的BRANCH复合MDLC得分与较高的血p-tau217水平显著相关 (经校正的std. β = -0.23,p = 0.031) 的情况.
  • 在BRANCH内部的数字标志测试主要推动了这种关联 (纠正了std. β = -0.22,p = 0.031) 的情况.
  • 在临床前阿尔茨海默氏症认知组合 (PACC-5) 和p-tau217水平 (经校正的std. β = -0.15,p = 0.187) 的情况.

结论:

  • 多天的BRANCH评估可以提高与早期AD病理生理学相关的微妙记忆缺陷的检测.
  • 将BRANCH等敏感的远程认知范式与等离子体生物标志物的结合,可以促进可扩展检测患有AD相关认知衰退风险的个体.
  • 在远程环境中,BRANCH显示出作为早期AD检测的敏感工具的潜力.