临床表现 临床表现
Chin Yee Cheong1,2, Li Cheng Heng3, Chong Jin Ng4
1Khoo Teck Puat Hospital, Singapore, United Kingdom.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
深白质病 (DWMH) 通过影响判断来间接影响对认知障碍的洞察力. 临床医生应监测患有DWMH的患者的判断和洞察力挑战.
科学领域:
- 神经学 神经学
- 认知神经科学 认知神经科学
- 老年病的医生 老年病的医生
背景情况:
- 视觉障碍是认知障碍的一个重大挑战,影响了诊断和护理.
- 白质病 (WMD) 与认知能力下降有关,但其对洞察力的具体影响尚不清楚.
- 了解WMD对洞察力的影响中介的认知途径至关重要.
研究的目的:
- 调查白质病 (WMD) 是否影响认知障碍患者的洞察力.
- 探索认知领域在大规模杀伤性武器和洞察力之间的关系中的调解作用.
主要方法:
- 133名患有轻度认知障碍或痴呆症的参与者使用Fazekas尺度对白质超强度 (WMH) 进行了评估,并使用临床洞察评级尺度进行了洞察.
- 结构方程建模 (SEM) 用于分析WMH亚型,认知领域和洞察力之间的直接和间接途径.
- 对相关共变量进行调整的分析.
主要成果:
- 深白质高强度 (DWMH),但不是周周结膜WMH,与洞察力差相关.
- 判断障碍与洞察力不佳密切相关.
- SEM显示DWMH通过判断障碍间接影响了洞察力,在调整后,这种途径仍然很重要.
结论:
- 深白质超强度 (DWMH) 主要通过它们对判断的影响来损害洞察力.
- 虽然痴呆症的严重程度是洞察力的强有力的预测指标,但DWMH判断链接表明结构变化推动了这些缺陷.
- 由DWM病变引起的前额子皮质回路的破坏可能是这些发现的基础,需要对受影响个体的判断和洞察力给予临床关注.
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