临床表现 临床表现
YongSoo Shim1, Yun Jeong Hong2, Bon D Ku3
1College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South).
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
粉样蛋白质斑块加速了中风后认知障碍 (PSCI) 患者的认知衰退. 虽然donepezil提供了暂时的好处,但早期粉样蛋白检测是个性化PSCI管理的关键.
科学领域:
- 神经学 神经学
- 神经科学是一个神经科学.
- 老年学是指老年学的学科.
背景情况:
- 脑卒中后认知障碍 (PSCI) 影响20-80%的中风幸存者.
- 粉样蛋白沉积,阿尔茨海默病的标志,可能会加剧PSCI的认知衰退.
- 这项研究研究了粉样质斑块对中风患者认知恶化的影响.
研究的目的:
- 为了研究粉样质斑块存在与PSCI患者的认知衰退之间的联系.
- 为了评估粉样蛋白沉积对12个月的认知测试成绩的影响.
- 评估donepezil治疗在粉素阳性PSCI患者中的疗效.
主要方法:
- 一项多中心前性观察队列研究,对192名患有认知障碍的急性缺血性中风患者进行了研究.
- 参与者通过PET扫描被分为粉样蛋白阳性 (n=40) 和粉样蛋白阴性 (n=152) 组.
- 在12个月内使用MMSE和MoCA评估认知功能;一些接受了donepezil.
主要成果:
- 粉样蛋白阳性患者表现出较低的基线MMSE得分 (19.03±6.30对比21.52±5.56,p=0.016).
- 12个月后,粉素阳性组MMSE改善较少 (19.48±6.70对比23.28±5.47,p=0.032) 和CDR-SOB评分恶化 (4.31±3.46对比2.63±2.82,p=0.051).
- 多内西尔在前6个月内在粉样蛋白阳性患者中提供了暂时的认知益处.
结论:
- 粉样斑块的存在与PSCI的加速认知衰退相关,由较低的MMSE和恶化的CDR-SOB表明.
- 多尼尼西尔显示出短期的疗效,但它对这一群体认知功能的长期影响是有限的.
- 早期识别粉样沉积对于开发定制治疗策略以有效管理PSCI至关重要.
相关概念视频
01:24Chronic Kidney Disease II: Clinical Manifestations
520
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
520
01:30Coronary Artery Disease III: Clinical Manifestations
299
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
299
01:25Endocarditis II: Clinical Features of Infective Endocarditis
364
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
364
01:26Heart Failure III: Clinical Manifestations
436
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
436
01:29Gastroesophageal Reflux Disease II: Clinical Features and Management
652
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
652
01:30Hypertension III: Clinical Manifestations and Diagnostic Studies
437
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
437