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临床表现 临床表现

Jonathan S Kim1, Ghasem Farahmand1, Maria G Corona1,2

  • 1University of California, Irvine, Irvine, CA, USA.

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概括
此摘要是机器生成的。

主观认知衰退 (SCD) 和微妙客观认知障碍 (sOCI) 一起表明发展为痴呆症的风险最高. 举报人报告的SCD是一个比自我报告的SCD或单独的SOCI更强的预测因素.

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科学领域:

  • 神经学 神经学
  • 认知科学 认知科学
  • 老年病的医生 老年病的医生

背景情况:

  • 主观认知衰退 (SCD) 和微妙的客观认知障碍 (sOCI) 与进展到轻度认知障碍 (MCI) 和痴呆症的风险增加有关.
  • 与患者报告的SCD相比,信息人报告的SCD表明未来衰退的可能性更高.
  • 对于认知衰退的sOCI与SCD的预测价值尚未得到充分理解.

研究的目的:

  • 检查SOCI和SCD对MCI或痴呆症进展风险的综合影响.
  • 为了确定信息人报告的SCD是否比患者报告的SCD更强有力的预测因素.
  • 评估sOCI是否提供超越SCD的预测价值.

主要方法:

  • 包括从UC Irvine ADRC开始时没有MCI或痴呆症的参与者.
  • 使用统一数据集 (UDS) 形式B9 (自我和告密者报告) 评估了SCD.
  • sOCI是通过在故事记忆和列表学习延迟回忆中平均值以下至少一个标准偏差的得分来定义的.

主要成果:

  • 患有SOCI和SCD的参与者表现出进展的最高风险.
  • 报告人报告的SCD (HR=2.97) 是最强的预测因素,其次是sOCI (HR=2.61) 和自我报告的SCD (HR=1.85).
  • 单独使用SCD的风险略高于单独使用sOCI的风险.

结论:

  • sOCI和SCD的结合使认知能力下降的风险最高,需要密切监测.
  • sOCI提供了超出自我报告SCD的独特预后价值,表明整合客观措施可以提高早期检测.
  • 举报人报告的SCD可以作为认知障碍的独立预测因素.