与COVID-19相关的神经和心理表现
Jo Ellen Wilson1,2,3, Deepti Gurdasani4, Raimund Helbok5,6
1Center for Critical Illness, Brain Dysfunction, and Survivorship (CIBS), Vanderbilt University Medical Center, Nashville, TN, USA. jo.e.wilson@vumc.org.
Nature reviews. Disease primers
|December 24, 2025
概括
长期COVID是SARS-CoV-2感染后的慢性疾病,在全球范围内影响着数以百万计的人,症状各异. 长期COVID的有效管理需要基于个体患者表现的个性化治疗.
科学领域:
- 传染性疾病 传染性疾病
- 神经学 神经学
- 免疫学 免疫学 免疫学
背景情况:
- 长期COVID是一种慢性疾病,发生在急性COVID-19后3个月内,症状持续至少3个月.
- 长期COVID影响全球8000万至4亿人,在社区发生率为5-20%,在住院患者中高达50%.
- 常见的症状包括神经精神问题 (记忆力丧失,焦虑,抑郁),头痛,睡眠障碍和头.
研究的目的:
- 总结临床表现,潜在的病理生理机制,以及长期COVID的管理考虑.
主要方法:
- 关于长期COVID症状,患病率和潜在机制的研究文献综述.
- 分析报告的病理生理因素,包括病毒持久性,免疫激活和自身免疫.
- 关于症状变异性和管理方法的临床观察结果的综合.
主要成果:
- 长期COVID呈现出广泛的神经精神和身体症状.
- 潜在的机制包括病毒的持久性,疹病毒的重新激活,失生症,自身免疫,凝固问题和免疫激活.
- 由于病情的异质性,管理策略必须是个性化的.
结论:
- 长期COVID是一种复杂的,多系统的疾病,具有重大的全球健康影响.
- 了解各种病理生理路径对于开发有效治疗方法至关重要.
- 对长期COVID患者来说,个性化,基于症状的管理是必不可少的.
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