对比曼尼托和聚乙烯甘醇在治疗肠道不良准备的患者中的疗效:一项随机对照临床研究
1Department of Gastroenterology, The First Affiliated Hospital of Ningbo University, Ningbo, 315010, China.
Techniques in coloproctology
|December 24, 2025
概括
曼尼托尔与聚乙烯糖醇 (PEG) 一样有效,用于在没有充分准备的情况下重复结肠镜检查的患者的肠道准备. 曼尼托尔显示出可比的安全性和更好的患者满意度,这表明它是.
科学领域:
- 胃肠病学 胃肠病学
- 临床试验 临床试验
- 医疗器械 医疗器械
背景情况:
- 结肠直肠癌 (CRC) 需要有效的肠道准备进行结肠镜检查.
- 不充分的肠道准备需要重复的程序,增加医疗保健负担.
- 对比曼尼托和聚乙烯甘醇 (PEG) 对于重复结肠镜准备至关重要.
研究的目的:
- 为了比较口服曼尼托尔与PEG的疗效和耐受性,用于在肠道准备不足的患者中重复结肠镜检查.
- 根据波士顿肠道准备量表 (BBPS) 的得分来评估曼尼托尔与PEG的非劣质性.
主要方法:
- 潜在的,开放标签,随机对照试验与盲目的终点.
- 包括134名年龄在18-75岁的患者,BBPS得分≤1.1.
- 使用1-L曼尼托或PEG溶液,通过BBPS测量结果,不良事件和患者满意度.
主要成果:
- 曼尼托尔在实现适当的肠道准备方面表现出与PEG相比的非劣势 (差异为3.0%).
- 曼尼托尔显示出有利的BBPS得分趋势和可比的安全概况 (17.9%对19.4%的不良事件).
- 与PEG相比,曼尼托尔获得了更高的患者满意度和更大的再利用意愿.
结论:
- 口服曼尼托是口服PEG的非劣质替代品,用于由于肠道准备不足而需要重复结肠镜检查的患者.
- 曼尼托尔具有可比的疗效和安全性,患者报告的结果有所改善.
- 这些发现支持曼尼托尔作为优化结肠镜准备的可行选择.
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