生物标志物 生物标志物
Stephan Duijkers1, Inez H G B Ramakers1,2, Kim Massloh1
1Alzheimer Center Limburg, School for Mental Health and Neuroscience, Maastricht University, Maastricht, Limburg, Netherlands.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
诸如高血压和高胆固醇血症之类的并发症与阿尔茨海默氏病 (AD) 病理学有关,这种病理学存在于具有正常认知和轻度认知障碍的个体中. 这些条件对粉样β和生物标志物产生差异性影响,影响AD诊断.
科学领域:
- 神经学 神经学
- 生物标志物 生物标志物
- 衰老研究研究 衰老研究
背景情况:
- 全球人口老龄化,导致阿尔茨海默病 (AD) 和相关疾病的发病率增加.
- 高血压 (HT),糖尿病 (DM) 和高胆固醇血症 (HCHOL) 是已知的痴呆症的危险因素.
- 这些并发症组合与阿尔茨海默病神经病理学之间的具体关联仍然不清楚.
研究的目的:
- 研究HT,DM和HCHOL的组合与AD病理的脑脊液 (CSF) 生物标志物之间的关联.
- 检查这些并发症与粉样β 42 (A) 和酸化 (T) 水平之间的关系.
主要方法:
- 分析了2479名正常认知 (NC) 和1618名轻度认知障碍 (MCI) 的参与者,这些参与者来自粉样蛋白生物标志物研究.
- 基于HT,DM或HCHOL存在的参与者的分类 (没有,一个或两个或更多的并发症).
- 使用数据驱动的切断值创建了四个粉样蛋白-β (A) 和酸化 (T) 生物标志物 (A-T-, A+T-, A-T+, A+T+) 档案.
主要成果:
- 在NC个体中,并发症与较高的A+T-配置文件和较低的A-T-配置文件有关.
- 在MCI患者中,并发症与较高的AT+配置文件和较低的AT-或AT+T+配置文件有关.
- 高血压和高胆固醇血症在NC和MCI两组中都与改变的AT生物标志物概况特别相关,而DM没有显著的差异关联.
结论:
- 伴随性疾病状态在正常认知和轻度认知障碍中不同地影响AD生物标志物概况.
- 高血压和高胆固醇血症,但不是糖尿病,显示与粉样蛋白和病理的明显关联.
- 研究结果表明,在记忆诊所的诊断策略中,考虑到并发症概况,可能会产生潜在的影响.
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