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临床表现 临床表现

Mark A Dubbelman1,2,3, Grace Ma2, Rebecca E Amariglio1,2,4

  • 1Harvard Medical School, Boston, MA, USA.

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此摘要是机器生成的。

老年人的神经精神症状 (NPS) 与较差的日常功能有关,甚至在认知能力下降明显之前. 解决这些症状可能会改善生活质量和日常表现.

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科学领域:

  • 老年精神病学是一门精神病学专业.
  • 神经退行性疾病 神经退行性疾病
  • 认知老龄化 认知老龄化

背景情况:

  • 神经精神病症状 (NPS) 可能在老年人中出现认知衰退,可能表明潜在的神经退行.
  • 日常生活工具活动 (IADLs) 变化是认知障碍的早期迹象,受到NPS的影响.
  • 这项研究侧重于NPS和认知不受损的老年人的日常功能.

研究的目的:

  • 检查自我和研究伙伴报告的NPS与认知不受损的老年人日常功能之间的关联.
  • 调查情绪症状 (抑郁,焦虑) 与日常功能之间的联系.
  • 测试NPS增加与日常运作状况较差相关的假设.

主要方法:

  • 177名认知正常的老年人和他们的研究伙伴参与了这项研究.
  • 评估包括NPS (MBI-C,AES,GDS,GAI,SHAPS) 和日常运作 (ADCS ADL-PI). 这些评估包括NPS (MBI-C,AES,GDS,GAI,SHAPS) 和日常运作 (ADCS ADL-PI).
  • 线性回归模型分析了截面关系,根据年龄,性别和教育程度进行了调整.

主要成果:

  • 自我报告的NPS (MBI-C,GDS,GAI) 和自我/研究伙伴报告的冷漠度评估量表 (AES) 与较差的自我报告的日常功能 (ADCS ADL-PI) 有关.
  • 研究伙伴报告的日常功能 (ADCS ADL-PI) 与SHAPS,MBI-C,AES,GDS和GAI相关.
  • 较差的日常生活工具活动 (IADL) 性能与神经精神病症状的增加有关.

结论:

  • 较大的NPS和情感症状 (抑郁,焦虑,无情,冷漠) 与认知不受损的老年人的日常功能相对应.
  • 在明显的认知障碍之前,识别和治疗NPS对于改善日常功能和生活质量至关重要.
  • 当使用它们作为临床试验结果时,请考虑症状源和IADL测量方法.