生物标志物 生物标志物
Filippos Anagnostakis1,2, Mehrshad Saadatinia1, Sarah Ko1
1Laboratory of AI and Biomedical Science (LABS), Columbia University, New York, NY, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
这项研究表明,阿尔茨海默病大脑缩的SPARE-AD成像特征随着年龄的增长而增加,并受性别和APOE ε4等位基因状态的影响. 在所有参与者中,大脑生物年龄差异与SPARE-AD显著相关.
科学领域:
- 神经成像是一种神经成像.
- 机器学习在医学中的应用
- 阿尔茨海默氏症疾病研究研究
背景情况:
- 在SPARE-AD (阿尔茨海默氏症进展的签名) 图像签名中研究了性别差异.
- 研究了SPARE-AD,年龄,APOE ε4等位基因和多器官生物年龄差距 (BAG) 之间的关系.
研究的目的:
- 为了确定与阿尔茨海默病相关的大脑缩特征的性别特异性模式.
- 评估遗传因素 (APOE ε4) 和生物年龄对这些特征的影响.
主要方法:
- 利用了来自iSTAGING和MULTI联盟的53622名认知正常参与者的数据.
- 使用支持矢量机器 (SPARE-AD模型) 来量化大脑缩.
- 应用了通用线性模型和ANCOVA来分析性别差异,BAG关联和APOE ε4效应.
主要成果:
- 随着年龄的增长,SPARE-AD得分增加,并且与APOE ε4等位基因的数量有关.
- 在SPARE-AD中观察到性别差异,年轻女性的得分更高,年长男性的得分更高.
- 大脑BAG显示与SPARE-AD的关联最强,其次是男性但不是女性的其他BAG显著.
结论:
- SPARE-AD显示了年龄和性别依赖的轨迹,突出了大脑的不同衰老模式.
- APOE ε4等位基因影响SPARE-AD,特别是在男性中,这表明性别特异性基因对神经退行症的影响.
- 生物年龄,特别是大脑年龄,是与大脑缩信号相关的关键因素,表明阿尔茨海默病风险.
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