生物标志物 生物标志物
Andrew Huynh1,2,3, Scott Wrigley1, James Andrews4
1Austin Health, Melbourne, VIC, Australia.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
在健康的老年人中,肌厚度 (TMT) 与尾骨肌量 (ASM) 相对应适度. 这表明,通过MRI测量的TMT可能是阿尔茨海默氏病研究中诊断肉症的实用工具.
科学领域:
- 老年学是一门学科.
- 神经学 神经学
- 放射学 放射学是一门学科.
背景情况:
- 萨科佩尼亚是一种与年龄相关的肌肉力量和质量的损失,与痴呆症和阿尔茨海默病 (AD) 有关.
- 诊断肉类症通常涉及通过DXA测量尾骨肌肉质量 (ASM),这在AD研究中不是标准的.
- 通过MRI测量的肌厚度 (TMT) 是肉症的潜在替代生物标志物.
研究的目的:
- 评估健康老年人中TMT和ASM之间的相关性.
- 为了确定TMT是否可以在AD研究中作为麻症的实用诊断工具.
主要方法:
- 从强烈体力活动和认知研究中对健康,认知无障碍的老年人的回顾性分析.
- 从脑MRI测量TMT;ASM计算并调整为高度的平方.
- 使用2019年欧洲工作组标准定义的肉;用于评估TMT-ASM和TMT-年龄关系的皮尔森相关性.
主要成果:
- 分析了95名参与者 (平均年龄69.1岁,53%为女性);11%的人患有肉症.
- 在TMT和ASM之间发现了中度正相关性 (r=0.41).
- TMT与年龄无关,但在患有和没有肉症的个体之间有显著差异 (p=0.004).
结论:
- 在没有认知障碍的老年人中,TMT与ASM有中度的相关性.
- 基于MRI的TMT评估可能是阿尔茨海默病研究中诊断肉症的可行方法.
- 需要进一步的研究来探索TMT与阿兹海默症患者临床结果的关系.
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