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Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
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生物标志物 生物标志物

Andrew Huynh1,2,3, Scott Wrigley1, James Andrews4

  • 1Austin Health, Melbourne, VIC, Australia.

Alzheimer's & dementia : the journal of the Alzheimer's Association
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PubMed
概括
此摘要是机器生成的。

在健康的老年人中,肌厚度 (TMT) 与尾骨肌量 (ASM) 相对应适度. 这表明,通过MRI测量的TMT可能是阿尔茨海默氏病研究中诊断肉症的实用工具.

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科学领域:

  • 老年学是一门学科.
  • 神经学 神经学
  • 放射学 放射学是一门学科.

背景情况:

  • 萨科佩尼亚是一种与年龄相关的肌肉力量和质量的损失,与痴呆症和阿尔茨海默病 (AD) 有关.
  • 诊断肉类症通常涉及通过DXA测量尾骨肌肉质量 (ASM),这在AD研究中不是标准的.
  • 通过MRI测量的肌厚度 (TMT) 是肉症的潜在替代生物标志物.

研究的目的:

  • 评估健康老年人中TMT和ASM之间的相关性.
  • 为了确定TMT是否可以在AD研究中作为麻症的实用诊断工具.

主要方法:

  • 从强烈体力活动和认知研究中对健康,认知无障碍的老年人的回顾性分析.
  • 从脑MRI测量TMT;ASM计算并调整为高度的平方.
  • 使用2019年欧洲工作组标准定义的肉;用于评估TMT-ASM和TMT-年龄关系的皮尔森相关性.

主要成果:

  • 分析了95名参与者 (平均年龄69.1岁,53%为女性);11%的人患有肉症.
  • 在TMT和ASM之间发现了中度正相关性 (r=0.41).
  • TMT与年龄无关,但在患有和没有肉症的个体之间有显著差异 (p=0.004).

结论:

  • 在没有认知障碍的老年人中,TMT与ASM有中度的相关性.
  • 基于MRI的TMT评估可能是阿尔茨海默病研究中诊断肉症的可行方法.
  • 需要进一步的研究来探索TMT与阿兹海默症患者临床结果的关系.