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相关概念视频

Infection01:20

Infection

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When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
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Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

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The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
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Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

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Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
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Pneumonia II: Pathophysiology01:29

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The pathophysiology of pneumonia involves the following steps:
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Stages of Infection01:26

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Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
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Defense Against Bacterial Pathogens01:31

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The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
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Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
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基础科学和病原发生学

Tatiana M Foroud1,2, Kelley M Faber1,2, Kaci Lacy1,2

  • 1National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD), Indianapolis, IN, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
PubMed
概括
此摘要是机器生成的。

研究人员可以通过共享生物样本数据来推进阿尔茨海默氏症和相关痴呆症 (ADRD) 研究. 国家阿尔茨海默病和相关痴呆症集中存储库 (NCRAD) 通过协议和数据共享实践来促进这一点.

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科学领域:

  • 神经科学是一个神经科学.
  • 生物医学研究生物医学研究
  • 数据科学数据科学数据科学

背景情况:

  • 推进阿尔茨海默氏症和相关痴呆症 (ADRD) 研究需要可访问的生物样本和共享数据.
  • 防止冗余的实验,并使先进的研究取决于有效的数据共享从有价值的研究样本.

研究的目的:

  • 概述国家阿尔茨海默氏症和相关痴呆症集中存储库 (NCRAD) 对广泛数据共享的承诺.
  • 详细说明NCRAD为生物存储库建立的标准操作程序和最佳实践,以支持数据共享.

主要方法:

  • 实施材料转移协议,要求与已批准的资源共享数据.
  • 分发盲目的样本,取消盲目的条件是原始数据返回数据共享资源.
  • 进行分发前的电话,讨论数据需求和格式.
  • 开发基于网络的样本选择和数据下载目录,在签署数据使用协议后可访问.

主要成果:

  • NCRAD采用三种主要的数据共享技术:材料转移协议,盲目样本分发和分发前的研究人员咨询.
  • 对于样本选择和数据分析,NCRAD已经开发了13个基于网络的目录,提高了可访问性.
  • 通过NCRAD目录的所有数据访问和样本选择都需要签署数据使用协议.

结论:

  • NCRAD致力于从生物样本中开放共享数据,这显著加速了ADRD研究的进展.
  • NCRAD的实践是其他生物存储库的典范,旨在促进生物医学研究中广泛的数据共享.