痴呆症护理研究和心理社会因素
Chitima Boongird1, Worapong Tearneukit2, Wannisa Wongpipathpong1
1Chakrinaruebodidra Institute, Ramathibodi Hospital, Mahidol University, Samutprakarn, Samutprakarn, Thailand.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
药物治疗和非药物治疗在阿尔茨海默病 (AD) 症状管理方面表现有前途. 将多尼佩西尔等治疗与认知疗法相结合可能会改善认知功能,但身体炼是功能状态的关键.
科学领域:
- 老年学和神经退行性疾病
- 基于证据的医学基于证据的医学.
- 临床药理学 临床药理学
背景情况:
- 阿尔茨海默病 (AD) 是全球痴呆和残疾的主要原因.
- 目前用于AD的药物疗法 (PT) 可能会引起不良影响.
- 非药物疗法 (NPT) 提供了替代方案,但缺乏对PT的比较疗效数据.
研究的目的:
- 进行对PT和NPT在AD患者的认知,行为和功能结果管理方面的比较有效性评估.
- 通过比较单个和组合的PT和NPT来确定最佳的治疗策略.
主要方法:
- 在Medline和Scopus数据库的系统文献搜索到2022年12月.
- 包括系统性审查和随机对照试验 (RCT) 评估PT,NPT或AD组合.
- 网络元分析 (NMA) 来比较干预措施,有效性使用积累性排名曲线 (SUCRA) 下的表面进行排名.
主要成果:
- 分析了153个RCT. 几项干预措施,包括多尼佩西尔与认知疗法 (CT) 和体育炼 (PE) 结合,显著改善了认知评分 (MMSE).
- 随着里瓦斯蒂格明加上认知刺激 (CS),单独PE和职业治疗 (OT),观察到行为症状的显著改善.
- 身体炼 (PE) 是唯一一项干预措施,显示了功能状态的显著改善.
结论:
- 结合PT和NPT,如多尼佩西尔+CT和里瓦斯蒂格明+CR,显示在阿尔茨海默病中潜在的认知益处.
- 身体炼 (PE) 成为改善阿兹海默症患者功能状态的关键干预措施.
- 需要进一步的研究来验证AD管理中联合治疗方法的有效性.
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