超低刺激强度的圣神经调节在便失禁中是有效的 - 从一阶段植入程序的随机研究中得出的结果
J Duelund-Jakobsen1,2, S Buntzen3,4,5, L Lundby3
1Pelvic Floor Unit, Department of Surgery, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200, Aarhus N, Denmark. jakob_jakobsen@hotmail.com.
Techniques in coloproctology
|December 24, 2025
概括
感官下神经神经调节 (SNM) 有效地治疗便失禁. 超低刺激幅度,即使在0.05V,也显示出与新植入患者的更高设置相匹配的功能结果.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
背景情况:
- 圣神经调节 (SNM) 通常使用感官值 (ST) 刺激强度.
- 然而,下感官刺激 (≤50%ST) 已在减少便失禁事件方面表现出有效性.
研究的目的:
- 在新植入SNM设备的患者中,研究功能结果和不同感官下刺激幅度之间的关系.
- 评估超低振幅刺激在治疗便失禁方面的有效性.
主要方法:
- 一项随机双盲研究包括了每周一次便失禁的患者,这些患者对保守治疗没有反应.
- 患者在术后随机分配,接受0.05V (G-1) 或90%ST (G-2) 的刺激,期间分别为50%和90%ST,然后在ST中接受12周.
- 结果被评估使用圣马克的失禁分数,视觉模拟尺度 (VAS) 满意度,和肠道习惯日记.
主要成果:
- 73名患者完成了试验;在所有组中,便失禁发作显著减少,没有组间差异.
- 在4周后,在肠功能的deltaVAS中观察到一个统计学上显著的差异,偏好G-2 (50点改善) 与G-1 (30点改善) (p=0.05).
- 与较高的振幅相比,G-1的超低振幅 (0.05V,~9.6%ST) 显示肠道功能的改善较低.
结论:
- 感官下刺激是新植入的便失禁患者可行的治疗选择.
- 0.05V的振幅似乎对整体功能结果和更高的刺激振幅一样有效,尽管在改善肠功能方面存在潜在的初始差异.
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