生物标志物 生物标志物
Soyoung Lee1, Sheena R Baratono1, Grace T Burt1
1Brigham and Women's Hospital, Boston, MA, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
阿尔茨海默病 (AD) 脑缩在没有认知障碍的个体中与不同的大脑网络有关. 识别这些网络有助于了解早期AD病理生理学和风险分层.
科学领域:
- 神经科学是一个神经科学.
- 医疗成像医学成像
- 老年学是一门学科.
背景情况:
- 阿尔茨海默病 (AD) 病理学,包括粉样β (Aβ) 积累,在认知衰退之前.
- 在临床前的AD中,Aβ相关的大脑缩和特定的认知网络之间的关系尚不清楚.
- 了解早期网络水平缩对于AD病理生理学和风险分层至关重要.
研究的目的:
- 为了确定在临床前的AD中是否有Aβ相关的大脑缩,将其映射到不同的认知网络中.
- 为了确定与早期AD的客观和主观认知变化相关的特定大脑网络.
- 探索缩网络映射的实用性,以了解临床前AD.
主要方法:
- 分析了1778名认知不受损的老年人 (65-85岁) 的结构性MRI和粉样蛋白βPET扫描.
- 使用顶点通用的一般线性模型创建个性化缩图.
- 使用规范的人类连接组估计缩模式的功能连接性.
- 线性回归以将缩连接性与客观 (PACC) 和主观 (CFI) 认知得分联系起来.
主要成果:
- 在临床前的AD中,针对客观和主观认知变化确定了不同的大脑网络.
- 缩模式连接到上时环与客观认知障碍 (PACC) 有关.
- 与中关联的缩模式与主观认知障碍 (CFI) 有关.
结论:
- 缩网络映射成功地确定了与临床前AD中过渡性认知变化相关的独特脑网络.
- 这些发现增强了对早期AD病理生理学的理解.
- 这种方法对于在临床前阿尔茨海默病中定位早期认知症状是有价值的,从阿尔茨海默病痴呆症扩展其应用.
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