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临床表现 临床表现

Leslie S Gaynor1, Alaina Durant1, Shubhabrata Mukherjee2

  • 1Vanderbilt University Medical Center, Nashville, TN, USA.

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概括
此摘要是机器生成的。

临主导的与年龄相关的TDP-43脑病变神经病变 (LATE-NC) 和阿尔茨海默氏病 (AD) 独特地影响中叶体积和认知能力下降. 在生活中识别LATE-NC对于理解其在痴呆症中的作用至关重要.

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科学领域:

  • 神经病理学神经病理学
  • 神经退行性疾病 神经退行性疾病
  • 认知老龄化 认知老龄化

背景情况:

  • 临主导的与年龄相关的TDP-43脑病变神经病理变化 (LATE-NC) 在痴呆症中很普遍,通常与阿尔茨海默病 (AD) 一起发生.
  • 缺乏LATE-NC的体内生物标志物阻碍了临床鉴定.
  • 这项研究调查了病理确认LATE-NC,AD,中叶 (MTL) 体积和认知轨迹之间的关系.

研究的目的:

  • 评估LATE-NC和AD神经病理与中叶 (MTL) 亚区域体积的关联.
  • 评估LATE-NC和AD对纵向认知衰退的影响.
  • 确定LATE-NC的临床相关物,以改善体内诊断.

主要方法:

  • 来自AD测序项目表型协调联盟的846名参与者 (70岁以上) 的分析.
  • 使用了协调的纵向认知领域得分 (记忆,执行功能,语言),神经病理学和遗传数据.
  • 使用MUSE对3T脑MRI扫描进行了细分;线性回归和混合效应模型评估了对MTL体积和认知衰退的病理影响.

主要成果:

  • 无论是AD还是LATE-NC病理都是与特定的MTL亚区域体积独特相关的,海马与LATE-NC相关,但不是AD.
  • 与没有LATE-NC的参与者相比,LATE-NC的参与者表现出更快的记忆衰退速度.
  • 阿尔茨海默病理与执行功能和语言的加速下降有关.

结论:

  • 阿德和LATE-NC与MTL体积和认知衰退模式有明显的关联.
  • 了解LATE-NC的临床表现对于其生命中识别至关重要.
  • 这项研究支持未来关于LATE-NC病原和临床管理的研究.