动脉样硬化相关指标与脂肪肝之间的关联:基于人口的观察性研究
Xiaoping Liu1, Ping Yuan2, Ying Huang3
1Rehabilitation Department, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, No. 1 Minde Road, Donghu District, Nanchang City, 330006, Jiangxi, China.
European journal of medical research
|December 25, 2025
概括
脂肪肝与心血管疾病指标有关,如动脉质指数 (AI),甘油三糖指数 (TyG) 和臂脚脉冲波速度 (baPWV). TyG指数显示了日本人口中脂肪肝的最佳预测值.
科学领域:
- 心血管健康 心血管健康
- 代谢综合征是代谢综合征的一种.
- 诊断生物标志物 诊断生物标志物
背景情况:
- 脂肪肝疾病越来越多地被认为与心血管疾病 (CVD) 有关.
- 脂肪肝与特定的动脉样硬化相关指数之间的相关性存在有限的研究.
- 了解这些联系对于早期发现和预防策略至关重要.
研究的目的:
- 在日本人口中调查动脉样硬化相关指标与脂肪肝之间的关联.
- 为了评估甘油三糖指数 (TyG),动脉动脉指数 (AI) 和手腕脚脉冲波速度 (baPWV) 对脂肪肝的预测值.
- 为了确定脂肪肝检测的潜在生物标志物.
主要方法:
- 从Dryad数据库中对909名日本人 (24-84岁) 的横截面分析.
- 数据包括体检,问卷,血液检查和成像 (脂肪肝腹部超声波).
- 测量了动脉样硬化指标:脂质谱,TyG指数,AI和baPWV-max.
主要成果:
- 在参与者中,脂肪肝的患病率为28.93%.
- AI,TyG和baPWV-max与脂肪肝显著相关.
- TyG指数显示了检测脂肪肝曲线下的最高面积 (AUC=0.7660) ,值为8.2611,表明高灵敏度和特异性.
结论:
- 三糖糖 (TyG) 指数,动脉质指数 (AI) 和脚脉冲波速度 (baPWV) 与日本人口中的脂肪肝有显著的相关性.
- 泰格指数,特别是超过8.2611时,与AI和baPWV-max相比,为脂肪肝提供了更好的预测值.
- 这些发现凸显了TyG作为脂肪肝评估的非侵入性生物标志物的潜力.
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