坎比洛巴克特菌 spp. 的流行率和抗菌素耐药性模式. 在伊朗 (2000-2025) 引起人类胃肠炎:系统性审查和元分析
Mozhgan Derakhshan-Sefidi1, Bita Bakhshi2, Farzaneh Hamidi3
1Department of Microbiology, Saveh University of Medical Sciences, Saveh, Iran.
BMC infectious diseases
|December 25, 2025
概括
坎比洛巴克菌感染在伊朗正在增加,抗生素耐药性的增加构成了治疗挑战. 加强监测和抗微生物药物管理对于公共卫生至关重要.
科学领域:
- 传染性疾病 传染性疾病
- 微生物学 微生物学
- 公共卫生 公共卫生
背景情况:
- 坎比洛细菌病是导致胃肠炎的全球重要原因之一.
- 伊朗坎比洛巴克特菌的流行率和抗菌素耐药性 (AMR) 的数据有限.
研究的目的:
- 估计伊朗全国坎皮洛巴克特相关胃肠炎的流行率.
- 分析20多年来感染率和抗生素耐药性模式的时间趋势.
主要方法:
- 在多个数据库 (2000-2025) 中进行系统的文献搜索,遵循PRISMA指南.
- 用随机效应模型对46项符合条件的研究进行元分析.
- 通过JBI关键评估检查清单进行质量评估,并使用R.
主要成果:
- 坎比洛巴克菌胃肠炎的整体综合患病率为8.0%,具有显著的异质性.
- 坎比洛巴克特 (Campylobacter jejuni) 的患病率比坎比洛巴克特大肠杆菌 (Campylobacter coli) 的患病率 (16.0%) 高 (35.0%).
- 观察到对诺 (西普洛克萨,纳利迪克酸) 和四环素的耐药性急剧增加,特别是在大肠杆菌中.
结论:
- 在伊朗,坎比洛巴克特菌感染的发病率中等但正在上升,其中C. jejuni是主要的物种.
- 对关键抗生素的抗菌素耐药性增加威胁到治疗疗效.
- 迫切需要加强监测,标准化诊断和抗菌药物管理,特别是在家禽来源方面.
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