临床表现 临床表现
Jason J Hassenstab1, Matthew S Welhaf2
1Washington University in St. Louis, St. Louis, MO, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
在症状出现之前,数字认知评估可以检测早期阿尔茨海默病 (AD) 变化. 这些远程,频繁的测试揭示了传统方法错过的认知变异性和学习缺陷,有助于早期AD检测和预防试验.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 生物医学工程 生物医学工程
背景情况:
- 临床前阿尔茨海默氏症 (AD) 缺乏明显的认知症状,这使得早期发现具有挑战性.
- 传统的认知测试对微妙的,症状前的认知变化提供了有限的见解.
- 数字认知评估的进步使得高频,远程数据收集成为可能.
研究的目的:
- 突出数字认知方法如何检测临床前阿尔茨海默病 (AD) 变化,而传统测试无法检测.
- 为了证明远程,高频认知评估的实用性,以了解AD对认知的影响.
- 探索数字评估作为AD预防试验中的新成果的潜力.
主要方法:
- 使用远程数字认知评估,随着时间的推移频繁地进行认知评估.
- 分析数据的结构,如人内变化,学习和忘记率等.
- 将数字评估结果与临床内测试和已确定的阿尔茨海默病 (AD) 生物标志物相关联.
主要成果:
- 老年人成功地参与远程数字研究,产生有效和可靠的认知变化估计.
- 具有遗传风险或AD生物标志物升高的个体表现出增加的认知变异性 (日复一日,日复一日,瞬间).
- 生物标志物阳性参与者显示学习减少和忘记率增加,表明临床前AD认知缺陷.
结论:
- 数字认知评估对临床前阿尔茨海默病 (AD) 很敏感.
- 高频,远程测试捕获了超越传统评估的临床意义上的认知构造.
- 这些数字方法为AD预防和治疗研究提供了新的结果措施.
相关概念视频
01:24Chronic Kidney Disease II: Clinical Manifestations
520
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
520
01:30Coronary Artery Disease III: Clinical Manifestations
299
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
299
01:25Endocarditis II: Clinical Features of Infective Endocarditis
364
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
364
01:26Heart Failure III: Clinical Manifestations
436
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
436
01:29Gastroesophageal Reflux Disease II: Clinical Features and Management
652
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
652
01:30Hypertension III: Clinical Manifestations and Diagnostic Studies
437
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
437