Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

749
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
749
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

516
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
516

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Variabilities of two Drechslerella dactyloides isolates in Korea and high predacity against Bursaphelenchus xylophilus.

Current microbiology·2010
Same author

Molecularly tuned peptide assemblies at the liquid-solid interface studied by scanning tunneling microscopy.

Physical chemistry chemical physics : PCCP·2010
Same author

[Resistance mutation patterns of hepatitis B virus in patients with suboptimal response to adefovir dipivoxil therapy after lamivudine resistance].

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology·2010
Same author

[Application of videomediastinoscopy in positive PET finding for mediastinal lymph node of lung cancer].

Zhongguo fei ai za zhi = Chinese journal of lung cancer·2010
Same author

Preliminary effect of proximal femoral nail antirotation on emergency treatment of senile patients with intertrochanteric fracture.

Chinese journal of traumatology = Zhonghua chuang shang za zhi·2010
Same author

Percentage of subjects with no heavy drinking days: evaluation as an efficacy endpoint for alcohol clinical trials.

Alcoholism, clinical and experimental research·2010
Same journal

Evidence for progressive neurodegeneration in iatrogenic cerebral amyloid angiopathy.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Human brain connectome profiles mediate the relationship between pathology burden and clinical phenotypes in Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Kat5 cKO mouse replicates biological domain signatures associated with Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Evaluation of CSF and plasma tau species as fluid surrogate candidates for tau PET in prodromal to moderate Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Associations of self-reported obstructive sleep apnea with cognition and dementia risk in cognitively unimpaired middle-aged adults.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Inflammation profiles in Alzheimer's disease relate to cognition and neurodegeneration.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
查看所有相关文章

相关实验视频

Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.1K

生物标志物 生物标志物

Lei Liu1

  • 1Division of Biostatistics, Washington University in St Louis, St Louis, MO, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
PubMed
概括
此摘要是机器生成的。

ITree-MMRM框架确定了轻度认知障碍 (MCI) 患者的认知评分较低,他们在36个月内从多尼佩西尔治疗中获益最多. 这促进了阿尔茨海默病 (AD) 管理的精准医学.

更多相关视频

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.9K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

702

相关实验视频

Last Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.1K
Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.9K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

702

科学领域:

  • 神经科学是一个神经科学.
  • 临床药理学 临床药理学
  • 生物统计学 生物统计学

背景情况:

  • 阿尔茨海默病 (AD) 和轻度认知障碍 (MCI) 的管理受到异质患者进展和治疗反应的挑战.
  • 精准医学需要识别患者子组,这些患者可以从多尼佩西尔等特定疗法中受益.
  • 针对性治疗策略对于改善AD和MCI治疗结果至关重要.

研究的目的:

  • 开发和应用一种新的框架 (ITree-MMRM) 来识别具有不同长期治疗效果的患者子组.
  • 确定MCI患者的特定亚组,这些患者从多尼尼西尔治疗中显现出显著的长期益处.
  • 为了增强个性化医疗方法在管理认知衰退.

主要方法:

  • ITree-MMRM框架将互动树 (ITree) 方法与重复措施混合模型 (MMRM) 集成在一起.
  • 应用于Donepezil在769名MCI患者的3年临床试验,使用临床痴呆症评分表 (CDR-SOB) 盒子总和得分.
  • 引导式修剪被用来改进子组的识别和减轻过度乐观.

主要成果:

  • 一个MCI小组具有较低的基线认知得分 (MMSE ≤24),在36个月后显示了多尼佩西尔的显著长期益处.
  • 具有较高基线认知分数的患者从治疗中获得的益处较小.
  • 模拟研究证实了ITree-MMRM框架的稳定性和优越性.

结论:

  • 在ITree-MMRM框架中,成功地确定了MCI子组,这些MCI子组对Donepezil的长期反应不同.
  • 这些发现支持个性化医疗策略,以优化多尼佩西尔治疗MCI和AD.
  • 需要在更大的临床试验中进一步验证,以证实这些针对性治疗见解.