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相关概念视频

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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生物标志物 生物标志物

Danni Ge1, Jiaming Lu1, Qian Chen1

  • 1Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
PubMed
概括
此摘要是机器生成的。

主观认知衰退 (SCD) 显示了中枢和侧侧内皮质 (MEC/LEC) 中大脑连接的改变. 这些变化与导航和记忆相关,表明sFC和dFC是潜在的早期阿尔茨海默病生物标志物.

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科学领域:

  • 神经成像是一种神经成像.
  • 认知神经科学 认知神经科学
  • 神经学 神经学

背景情况:

  • 主观认知衰退 (SCD) 代表了认知障碍的早期阶段.
  • 中间内耳皮层 (MEC) 和侧面内耳皮层 (LEC) 对于记忆和导航至关重要.
  • 研究MEC和LEC的功能连接性可能会揭示早期的病理变化.

研究的目的:

  • 检查SCD个体的MEC和LEC中的静态功能连接 (sFC) 和动态功能连接 (dFC).
  • 在SCD中探索功能连接,认知表现,空间导航和嗅觉记忆之间的关系.
  • 评估sFC和dFC作为阿尔茨海默病 (AD) 早期诊断生物标志物的潜力.

主要方法:

  • 招募了77名对照对象和106名患有SCD的个人.
  • 通过神经心理评估,空间导航测试,嗅觉记忆测试和静止状态功能磁共振成像 (rs-fMRI) 收集数据.
  • 分析了双边MEC和LEC的静态和动态功能连接 (sFC和dFC).

主要成果:

  • 与对照人群相比,SCD个体在与各种大脑网络和区域的LEC和MEC连接中显示sFC降低.
  • 观察到dFC的变化,其中一些连接在SCD中减少,而另一些则增加.
  • 在SCD组中,MEC体积和空间导航,LECsFC和嗅觉功能,以及LECdFC和全球认知之间发现了积极的相关性.
  • 结合的sFC和dFC生物标志物实现了SCD识别曲线下的92.1%的面积.

结论:

  • 耳鼻皮层 (EC) 亚区域在SCD患者中表现出功能性改变.
  • LEC连接与空间导航有关,而MEC连接与嗅觉记忆有关.
  • 结合的sFC和dFC指标显示出作为神经成像生物标志物的前景,用于早期诊断AD.