生物标志物 生物标志物
Danni Ge1, Jiaming Lu1, Qian Chen1
1Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
主观认知衰退 (SCD) 显示了中枢和侧侧内皮质 (MEC/LEC) 中大脑连接的改变. 这些变化与导航和记忆相关,表明sFC和dFC是潜在的早期阿尔茨海默病生物标志物.
科学领域:
- 神经成像是一种神经成像.
- 认知神经科学 认知神经科学
- 神经学 神经学
背景情况:
- 主观认知衰退 (SCD) 代表了认知障碍的早期阶段.
- 中间内耳皮层 (MEC) 和侧面内耳皮层 (LEC) 对于记忆和导航至关重要.
- 研究MEC和LEC的功能连接性可能会揭示早期的病理变化.
研究的目的:
- 检查SCD个体的MEC和LEC中的静态功能连接 (sFC) 和动态功能连接 (dFC).
- 在SCD中探索功能连接,认知表现,空间导航和嗅觉记忆之间的关系.
- 评估sFC和dFC作为阿尔茨海默病 (AD) 早期诊断生物标志物的潜力.
主要方法:
- 招募了77名对照对象和106名患有SCD的个人.
- 通过神经心理评估,空间导航测试,嗅觉记忆测试和静止状态功能磁共振成像 (rs-fMRI) 收集数据.
- 分析了双边MEC和LEC的静态和动态功能连接 (sFC和dFC).
主要成果:
- 与对照人群相比,SCD个体在与各种大脑网络和区域的LEC和MEC连接中显示sFC降低.
- 观察到dFC的变化,其中一些连接在SCD中减少,而另一些则增加.
- 在SCD组中,MEC体积和空间导航,LECsFC和嗅觉功能,以及LECdFC和全球认知之间发现了积极的相关性.
- 结合的sFC和dFC生物标志物实现了SCD识别曲线下的92.1%的面积.
结论:
- 耳鼻皮层 (EC) 亚区域在SCD患者中表现出功能性改变.
- LEC连接与空间导航有关,而MEC连接与嗅觉记忆有关.
- 结合的sFC和dFC指标显示出作为神经成像生物标志物的前景,用于早期诊断AD.
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