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Infection01:20

Infection

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When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
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Urinary Tract Infection II: Pathophysiology01:25

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Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
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基础科学和病原发生学

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中年暴露于二二二乙烯 (DDE) 改变脂肪酸和氨基酸代谢,反映了与认知衰退和阿尔茨海默病 (AD) 相关的变化. 这些发现表明AD风险的潜在早期生物标志物.

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科学领域:

  • 环境健康 环境健康
  • 代谢学 代谢学 代谢学
  • 神经退行性疾病 神经退行性疾病

背景情况:

  • 血清二二二乙烯 (DDE) 是DDT的代谢物,与认知障碍和阿尔茨海默病 (AD) 风险有关.
  • 高分辨率的代谢学揭示了与早期认知变化和AD相关的代谢表型.
  • 与DDE相关的中年血清中的代谢变化,先前的认知功能障碍需要表征.

研究的目的:

  • 描述与二二二乙烯 (DDE) 暴露相关的中年血清代谢变化.
  • 调查潜在的代谢前体,以认知功能障碍和AD.

主要方法:

  • 从儿童健康和发育研究 (CHDS) 队列中分析了362名受试者.
  • 使用LC-MS和GC-MS对中年血清p,p'-DDE,代谢组和暴露组进行横截面分析.
  • 整个代谢组的关联研究 (MWAS),以确定与DDE相关的代谢途径.

主要成果:

  • p,p'-DDE与脂肪酸代谢途径的改变有关 (卡尼丁穿,生物合成,阿拉基酸,前列腺素,甘油脂).
  • 氨酸和阿斯巴酸氨基酸的新陈代谢与p,p'-DDE有关.
  • 观察到必需脂肪酸 (DHA,EPA) 和乙卡尼丁的水平降低,血清p,p'-DDE的增加.

结论:

  • 中年期与DDE相关的代谢变化与与认知功能障碍和AD相关的代谢变化重叠.
  • 这些发现突出了潜在的代谢媒介在认知衰退和AD发病.
  • 相关的中年血清DDE和代谢组可能会阐明AD的生物机制.