基础科学和病原发生学
Carolyn Accardi1, Mary Nellis1, Bill Liang1
1Emory University School of Medicine, Atlanta, GA, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
中年暴露于二二二乙烯 (DDE) 改变脂肪酸和氨基酸代谢,反映了与认知衰退和阿尔茨海默病 (AD) 相关的变化. 这些发现表明AD风险的潜在早期生物标志物.
科学领域:
- 环境健康 环境健康
- 代谢学 代谢学 代谢学
- 神经退行性疾病 神经退行性疾病
背景情况:
- 血清二二二乙烯 (DDE) 是DDT的代谢物,与认知障碍和阿尔茨海默病 (AD) 风险有关.
- 高分辨率的代谢学揭示了与早期认知变化和AD相关的代谢表型.
- 与DDE相关的中年血清中的代谢变化,先前的认知功能障碍需要表征.
研究的目的:
- 描述与二二二乙烯 (DDE) 暴露相关的中年血清代谢变化.
- 调查潜在的代谢前体,以认知功能障碍和AD.
主要方法:
- 从儿童健康和发育研究 (CHDS) 队列中分析了362名受试者.
- 使用LC-MS和GC-MS对中年血清p,p'-DDE,代谢组和暴露组进行横截面分析.
- 整个代谢组的关联研究 (MWAS),以确定与DDE相关的代谢途径.
主要成果:
- p,p'-DDE与脂肪酸代谢途径的改变有关 (卡尼丁穿,生物合成,阿拉基酸,前列腺素,甘油脂).
- 氨酸和阿斯巴酸氨基酸的新陈代谢与p,p'-DDE有关.
- 观察到必需脂肪酸 (DHA,EPA) 和乙卡尼丁的水平降低,血清p,p'-DDE的增加.
结论:
- 中年期与DDE相关的代谢变化与与认知功能障碍和AD相关的代谢变化重叠.
- 这些发现突出了潜在的代谢媒介在认知衰退和AD发病.
- 相关的中年血清DDE和代谢组可能会阐明AD的生物机制.
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