生物标志物 生物标志物
Ying Xia1,2, Vincent Dore3,4, Jurgen Fripp1
1CSIRO Health and Biosecurity, Australian E-Health Research Centre, Brisbane, QLD, Australia.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
在临床前阿尔茨海默氏症 (AD) 中,记忆评估对增加粉样β (Aβ) 水平的个体的认知变化最为敏感. 这凸显了记忆测试在新兴AD临床试验中的重要性.
科学领域:
- 神经学 神经学
- 生物标志物 生物标志物
- 认知科学 认知科学
背景情况:
- 阿尔茨海默病 (AD) 临床试验经常使用临床前阿尔茨海默病认知复合 (PACC) 评分,结合记忆,执行功能和心理状态措施.
- 在新出现的AD阶段的认知措施的敏感性,其特点是粉样β (Aβ) 水平在正常范围内上升,仍然未被评估.
研究的目的:
- 为了比较不同认知复合分数在检测Aβ相关的认知衰退的灵敏度,最初认知不受损 (CU) 个体.
- 评估与增加的Aβ水平相关的认知变化,这表明新出现的AD.
主要方法:
- 利用了澳大利亚成像,生物标志物和生活方式 (AIBL) 研究中的611个CU个体的数据,最初是Aβ阴性.
- 使用四个复合分数评估认知变化:PACC,PACC5 (包括语义流),没有MMSE的PACC5,以及仅记忆的复合.
- 采用线性混合效应模型 (LMM) 来比较变得Aβ阳性 (新兴AD) 和保持Aβ阴性 (稳定CU Aβ-) 个体之间的认知变化率.
主要成果:
- 在611名CU参与者中,有86人发展出新兴的AD,其特点是Aβ积累速度更快.
- 对于PACC,PACC5 (不包括MMSE) 和内存复合物,观察到具有统计学意义的按时间分组相互作用.
- 记忆复合体表现出最强的效果,表明对Aβ相关的认知变化敏感度最高 (β[SE] = -0.089[0.029],p = 0.003).
结论:
- 记忆复合是检测Aβ相关变化的最敏感的认知测量方法,用于在新出现的AD阶段中检测Aβ水平增加的个体.
- 针对新出现的AD的临床试验应纳入记忆评估,以有效地捕捉AD相关的认知变化.
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