临床表现 临床表现
Joseph Eichenbaum1, Miriam T Ashford1,2, Chengshi Jin1
1University of California, San Francisco, San Francisco, CA, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
像pTau217和GFAP这样的等离子体生物标志物与老年人的主观认知衰退和记忆问题相关. 这种远程查方法有助于识别患阿尔茨海默病 (AD) 风险的个体.
科学领域:
- 神经学 神经学
- 生物标志物发现发现
- 老年学是指老年学的学科.
背景情况:
- 血生物标志物显示出早期阿尔茨海默病 (AD) 检测的希望.
- 主观认知衰退 (SCD) 代表了AD连续体中的早期症状阶段.
- 血生物标志物在SCD群体中的实用性仍未得到充分探索.
研究的目的:
- 在一个远程队列中研究血AD生物标志物水平和主观/客观认知指标之间的关系.
- 评估可扩展的远程数据收集,用于AD查和监测的潜力.
主要方法:
- 629名参与者 (55+) 接受了远程抽血以进行血分析.
- 测量的等离子体生物标志物包括NFL,Aβ42/40,pTau231,pTau217和GFAP.
- 线性回归分析了生物标志物和认知尺度 (ECog,记忆问题,Cogstate) 之间的关联.
主要成果:
- 升高的pTau217和pTau231水平与自我报告的记忆问题相关.
- 较高的pTau217和GFAP与ECog尺度上自我报告的认知衰退增加有关.
- 血生物标志物与客观认知表现 (Cogstate) 之间没有发现显著的关联.
结论:
- 远程,无监督的SCD和记忆问题的数字测量可以识别高血pTau和GFAP的个体.
- 这种方法有效地识别了与AD相关的认知障碍风险的老年人.
- 这种可扩展的方法促进了临床试验招募,观察性研究和临床护理查.
相关概念视频
Chronic Kidney Disease II: Clinical Manifestations
520
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
520
Coronary Artery Disease III: Clinical Manifestations
299
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
299
Endocarditis II: Clinical Features of Infective Endocarditis
364
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
364
Heart Failure III: Clinical Manifestations
436
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
436
Gastroesophageal Reflux Disease II: Clinical Features and Management
652
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
652
Hypertension III: Clinical Manifestations and Diagnostic Studies
437
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
437


