Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

749
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
749
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

516
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
516

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Global Socioeconomic Context and Brain Ageing in Epilepsy: an ENIGMA-Epilepsy study.

medRxiv : the preprint server for health sciences·2026
Same author

Cortical gray-white matter contrast alterations precede amyloid-β positivity and macrostructural changes in older adults without dementia.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Mediation Analysis Between Brain Age, Disease-Modifying Factors, and Disability and Cognitive Performance in Multiple Sclerosis.

Neurology·2026
Same author

Music processing in behavioural variant frontotemporal dementia and Alzheimer's disease: a functional MRI study.

Brain communications·2026
Same author

Amsterdam IMAging and Clinical GliOma Dataset; IMAGO.

Scientific data·2026
Same author

Decreased amyloid-related structure-function coupling in preclinical Alzheimer's disease.

Communications medicine·2026
Same journal

Multimorbidity burden and patterns associated with DeepBrainNet-derived brain-age gap in dementia-free older adults: A community-based study.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Reply to "Shifting the emphasis of brain health literacy from individuals to systems to reduce inequalities".

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Shifting the emphasis of brain health literacy from individuals to systems to reduce inequalities.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Correlates and predictors of self-efficacy among dementia caregivers: D-CARE findings.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

What should convince a clinician of disease modification in Alzheimer's disease clinical trials?

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Primary cilia-extracellular vesicle crosstalk in Alzheimer's disease: Emerging mechanisms and biomarker potential.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
查看所有相关文章

相关实验视频

Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.1K

生物标志物 生物标志物

Mario Tranfa1, Leonard Pieperhoff1, Giuseppe Pontillo1,2,3

  • 1Amsterdam University Medical Center (Amsterdam UMC), Amsterdam, North Holland, Netherlands.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
PubMed
概括
此摘要是机器生成的。

阿尔茨海默病 (AD) 的多基因风险得分影响白质 (WM) 完整性. 遗传易感性与AD病理相互作用,通过不同的生物学途径影响WM纤维密度和横截面.

更多相关视频

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.9K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

702

相关实验视频

Last Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.1K
Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.9K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

702

科学领域:

  • 神经科学是一个神经科学.
  • 遗传学 遗传学是一种遗传学.
  • 生物标志物 生物标志物

背景情况:

  • 阿尔茨海默病 (AD) 诊断正在转向像粉样蛋白-β1-42 (Aβ1-42) 和酸化-Tau181 (p-Tau181) 这样的生物标志物.
  • 并非所有Aβ1-42沉积的个体都会发展为AD,这表明其他因素也会影响疾病的易感性.
  • 多基因路径及其与AD病理学的相互作用可能解释大脑易感性的变化.

研究的目的:

  • 调查特定途径的多基因风险评分 (PRS) 对白质 (WM) 完整性的影响.
  • 探索AD病理 (Aβ1-42,p-Tau181) 和PRS在调节WM纤维密度 (FD) 和纤维截面 (FC) 之间的相互作用.
  • 利用基于fixel的方法来分析与遗传风险和AD生物标志物相关的WM变化.

主要方法:

  • 来自欧洲预防阿尔茨海默氏症痴呆症 (EPAD) 队列的803名非痴呆症参与者的分析.
  • 进行了基因组测序,脑脊液 (CSF) Aβ1-42和p-Tau181测量以及扩散MRI测量.
  • 路径特定的PRS是基于由生物功能分组的AD相关遗传变异构建的. 线性模型评估了对FD和FC的影响,并对共变量和多重比较进行了校正.

主要成果:

  • p-Tau181表现出与FD的多相关系.
  • 迁移途径PRS与增加的FD和FC有关,特别是在左半球.
  • Aβ1-42和p-Tau181分别调节了清除和免疫激活途径PRS对FD的影响,证明了病理依赖的遗传影响.

结论:

  • 阿尔茨海默病的多基因风险直接影响了WM的完整性.
  • 对临床前AD病理学的遗传易感性涉及特定的生物过程,这些过程会对WM完整性产生差异性影响.
  • 了解这些相互作用对于阐明AD病原和变异性至关重要.