胚胎发育中的EPITranscriptomic修改:对自然和ART诱导的机制和影响的洞察
Alessandro M Volsa1, Eva R Hoffmann2, Pablo J Ross3
1Department of Physiology, International Excellence Campus for Higher Education and Research (Campus Mare Nostrum), University of Murcia, Murcia, Spain.
Human reproduction update
|December 25, 2025
概括
辅助生殖技术 (ART) 可以破坏胚胎中的关键RNA修饰,影响发育和健康. 了解表体转录学调节是提高ART安全性和有效性的关键,以获得更好的生殖结果.
科学领域:
- 生殖生物学 生殖生物学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 发育生物学 发展生物学
背景情况:
- 哺乳动物胚胎的发育依赖于复杂的分子调节.
- 辅助生殖技术 (ART) 在全球范围内广泛用于人类和动物的生育.
- 像N6-甲基氨酸 (m6A) 这样的表皮转录标记在发育过程中调节基因表达,但ART的影响尚不清楚.
研究的目的:
- 审查表体转录组修饰在自然受孕和ART受孕胚胎中的作用.
- 检查RNA修饰如何影响游戏生成和早期胚胎发育.
- 探索ART诱导的压力如何影响这些调节层和后代的健康.
主要方法:
- 在PubMed和Scopus搜索同行评审的文章和评论.
- 使用的关键词:"表体转录学"",RNA修饰"",子体生成"",胚胎发育"",ART".
- 批判性地评估和讨论到当年的相关出版物.
主要成果:
- 表体转录组修饰,特别是m6A,是RNA代谢的关键调节者,在游戏生殖和早期胚胎发育中发挥作用.
- ART压力因素 (氧化失衡,荷尔蒙刺激,冷保存) 可以扰乱RNA甲基化 (m1A,5-甲基氨酸).
- 这些变化影响了胚胎能力,胎盘功能,血统特征和后代发育,突出了作为生物标志物和目标的表体转录体标记.
结论:
- 了解ART对表皮转录组的影响对于改善生殖结果至关重要.
- 试管婴儿手术可能会对子细胞和胚胎中的RNA调节产生负面影响,导致植入失败和怀孕流产.
- 对表皮转录组修饰的洞察力指导了更安全,更有效的ART实践.
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