生物标志物 生物标志物
Hui Zhao1, Wenting Song2, Haifeng Chen2
1Department of Neurology, Affiliated Drum Tower Hospital, Nanjing University Medical School, Nanjing, China.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
APOEε4基因改变了阿尔茨海默病 (AD) 患者的默认模式网络 (DMN) 功能梯度,特别是在右叶. 这种干扰与认知能力下降相关,并且可能受到AD生物标志物的影响.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 遗传学 是一个
- 医疗成像医学成像
背景情况:
- APOEε4等位基因是阿尔茨海默病 (AD) 的重要危险因素.
- 功能连接梯度为分析大脑网络组织提供了一种新的方法.
- 了解APOEε4如何影响AD的这些梯度至关重要.
研究的目的:
- 调查APOEε4等位基因对默认模式网络 (DMN) 功能连接梯度在阿尔茨海默病中的影响.
- 探索DMN功能梯度和与APOEε4状态相关的认知功能之间的相关性.
- 检查AD生物标志物在调解APOEε4和DMN功能梯度之间的关系中的作用.
主要方法:
- 招募了271名受试者 (健康对照和AD患者,有或没有APOEε4载体).
- 利用认知功能测试,AD生物标志物血液测试和静止状态功能磁共振成像 (rs-fMRI).
- 采用双因素ANOVA,相关性测试和调解分析来评估关系.
主要成果:
- 在右叶中发现了APOEε4存在与DMN功能梯度之间的相互作用.
- 在非载体中,AD显示较高的DMN梯度;在载体中,AD显示较低的DMN梯度.
- 患有AD的APOEε4载体表现出DMN功能梯度的降低,与认知功能有积极的相关性,并且由AD生物标志物调解.
结论:
- APOEε4基因显著影响AD患者右叶的DMN功能梯度.
- 患有AD的APOEε4载体经历了更大的功能网络乱,与认知恶化有关.
- 阿尔茨海默病的生物标志物可能会影响DMN的功能梯度,影响阿尔茨海默病的静止状态功能连接.
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