临床表现 临床表现
Eunsun Gill1, Flor Alvarado2, David J Libon3,4
1Celia Scott Weatherhead Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
功能轨迹的下降,无论高低,都与中年认知功能较差有关. 保持稳定的估计膜过率 (eGFR) 对于在整个成年期保持认知健康至关重要.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 神经学 神经学
- 老年学是指老年学的学科.
背景情况:
- 估计的淋巴细胞过率 (eGFR) 显示了与认知功能 (CF) 的非线性关联.
- eGFR轨迹对中年认知功能的长期影响仍未得到充分研究.
- 这项研究利用了波加卢萨心脏研究 (BHS) 的数据来探索这种关系.
研究的目的:
- 调查成年期不同EGFR轨迹与中年期认知功能之间的关联.
- 识别eGFR随时间变化的模式及其与各种认知领域的相关性.
主要方法:
- 潜在类增长分析从721名BHS参与者中确定了3个eGFR轨迹类,这些参与者进行了多次成人肌素测量.
- 用记忆,工作记忆,注意力和处理速度测试来评估认知功能,通过平均分数计算全球CF.
- 多变量回归分析调整了人口和临床因素,以确定eGFR轨迹和CF之间的关联.
主要成果:
- 确定了三个eGFR轨迹:"高稳定下降趋势" (46.7%),"上升到下降趋势" (28.7%) 和"低稳定下降趋势" (24.4%).
- 与上下趋势相比,高稳定向下和低稳定向下的eGFR轨迹都与全球认知功能显著下降有关.
- 特定的认知领域,包括情节性记忆,工作记忆,注意力和图形运动信息处理速度 (GIPS),受到两种下降eGFR趋势的负面影响.
结论:
- 成年期eGFR的高和低稳定下降趋势都与全球认知功能和中年期特定认知领域的下降有关.
- 与持续下降趋势相比,向上向下的eGFR轨迹与更好的认知结果有关.
- 这些发现凸显了维持稳定的功能在整个寿命中保持认知健康的关键作用.
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