生物标志物 生物标志物
Xuefeng Ma1, Bing Zhang1, Futao Chen1
1Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
主观认知衰退 (SCD) 患者表现出神经血管合 (NVC) 和空间导航受损,与临床前阿尔茨海默病 (AD) 有关. 这种大脑NVC脱可能解释SCD个体的导航缺陷.
科学领域:
- 神经科学是一个神经科学.
- 医疗成像医学成像
- 阿尔茨海默氏症疾病研究研究
背景情况:
- 主观认知衰退 (SCD) 代表了临床前阿尔茨海默病 (AD) 的高风险组.
- 神经血管合 (NVC),神经元活动和脑血流 (CBF) 之间的关系,为神经退行性疾病提供了洞察力.
- 空间导航障碍是SCD的早期指标,但其与超高场MRI评估的NVC变化之间的联系仍然不清楚.
研究的目的:
- 研究SCD患者的NVC变化及其与空间导航功能的关联.
- 使用先进的5.0TMRI技术,包括动脉旋转标记 (ASL) 和多回声功能MRI (fMRI),用于高分辨率成像.
主要方法:
- 招募了30名正常对照 (NC) 和29名SCD个体进行全面评估.
- 使用ASL测量CBF,使用fMRI分析脑活动 (ALFF,fALFF).
- 组之间的NVC (CBF/ALFF,CBF/fALFF比率) 的比较,以及与空间导航,认知表现和等离子体生物标志物相关的发现.
主要成果:
- SCD个体表现出减少的NVC和较差的空间导航性能.
- 在SCD组中,在特定的大脑区域观察到明显较低的CBF和CBF/ALFF,CBF/fALFF比率.
- NVC比率,等离子体生物标志物和空间导航性能显示出显著的相关性,图像和导航数据的结合实现了SCD的高分类准确性.
结论:
- SCD群体表现出受损的NVC和空间导航缺陷,显着相互关联.
- 大脑NVC脱被提出为SCD中空间导航障碍的潜在神经病理机制.
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