创伤后应激障碍和癌症:一些有趣的相似之处和差异
Alan L Peterson1,2,3
1Department of Psychiatry and Behavioral Sciences, UT Health San Antonio, San Antonio, TX 78229, United States.
Military medicine
|December 25, 2025
概括
癌症领域为推进创伤后应激障碍 (PTSD) 研究和治疗提供了路线图,突出了退伍军人诊断,资金和患者倡导方面的差异.
科学领域:
- 比较医学是一种比较医学.
- 精神病学是一个精神病学.
- 在瘤学瘤学.
背景情况:
- 美国军人和退伍军人的创伤后应激障碍 (PTSD) 研究已经在20多年里取得了进展,但仍面临着挑战.
- 癌症研究领域在过去的七十年中取得了重大进展,克服了障碍,成为一个潜在的模型.
- 癌症和PTSD之间存在诊断分类,研究资金,临床试验持续时间和患者倡导的关键差异.
研究的目的:
- 审查癌症和PTSD的临床和研究方法之间的相似性和差异.
- 探索癌症领域的成功如何能够告知和推进PTSD研究和治疗策略.
- 确定改善PTSD诊断,治疗结果和患者参与的潜在策略.
主要方法:
- 对癌症 (200多种类型) 和PTSD (目前只有一种类型) 的诊断标准进行比较分析.
- 对两种疾病的研究资金分配和临床试验历史的审查.
- 审查知情同意流程,不良事件监测和临床试验中的患者退学率.
主要成果:
- 癌症研究受益于更多的资金和更长的历史,导致更多的诊断亚型和治疗进展.
- 创伤后应激障碍的临床试验因较差的结果而受到批评,尽管最近的试验显示有所改善;缺乏系统的不良事件监测.
- 在癌症中减少耻辱和生存倡导与持续的耻辱和有限的关注PTSD的'治愈'或缓解形成鲜明对比.
结论:
- 癌症研究的既定框架,包括其诊断细分化和患者倡导,为PTSD提供了宝贵的教训.
- 实施系统的不良事件监测和促进幸存者宣传可以改善PTSD治疗参与度和结果.
- 在PTSD研究中强调缓解和治愈的范式转变,受到癌症研究成功的启发,对于服务成员和退伍军人来说是有必要的.
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