生物标志物 生物标志物
Olivier Parent1,2, Sophia Osborne1, Gabriel A Devenyi1,2
1McGill University, Montreal, QC, Canada.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
一般来说,女性比男性有更多的白质超强度 (WMH) 和严重的病理生理学. 然而,男性的WMH体积更高,后部地区的方向分散更差,表明了复杂的性别特异性模式.
科学领域:
- 神经成像是一种神经成像.
- 神经病理学神经病理学
- 生物标志物 生物标志物
背景情况:
- 白质强度过高 (WMH) 的病理生理学因区域而异,包括,炎症,脱髓化和轴突退化.
- 女人比中年男性有更高的WMH负担,可能是由于更年期期间雌激素减少.
- 目前尚缺少跨性别的WMH病理生理学的详细空间特征.
研究的目的:
- 研究白质强度过高 (WMH) 病理生理学的空间模式中的性别差异.
- 通过微结构磁共振成像 (MRI) 以高空间分辨率在体内描述WMH病理生理学.
主要方法:
- 利用英国生物库数据 (n=32,526) 与扩散和敏感度加权的MRI来导出微结构标记.
- 应用了规范建模来确定特定于年龄和性别的健康白质微观结构值.
- 采用光谱集群来识别空间WMH病理生理学集群 (周腹腔,后腔,前腔) 并使用线性模型分析性别差异.
主要成果:
- 女性通常表现出更高的WMH体积和更严重的WMH病理生理学.
- 雄性在后部WMH中显示出更高的WMH体积和更差的方向分散 (OD) 病理生理学.
- 在控制WMH体积时,雌性在周周结膜和后部区域表现出强烈的影响,而OD在周周结膜区域内的雄性表现出显著更高的影响.
结论:
- 在WMH中,呈现出细微的,性别特异的空间效应.
- 与男性相比,女性有更多的WMH,但与男性相比,前部WMH病理生理学类似.
- 与雌性相比,雄性呈现较高的WMH体积,但后部WMH病理生理学减少.
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