临床表现 临床表现
Jacob Ziontz1, Piyush Maiti2, Jiaxiuxiu Zhang2
1Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
非对称的神经成像模式在早期发病的阿尔茨海默病 (EOAD) 中很常见,并且与特定的认知缺陷有关. 分析这种不对称可能有助于预测不同EOAD表现的早期认知衰退.
科学领域:
- 神经成像是一种神经成像.
- 阿尔茨海默氏症疾病研究研究
- 认知神经科学 认知神经科学
背景情况:
- 在阿尔茨海默病 (AD) 中注意到不对称的神经成像发现.
- 在早期发病的AD (EOAD) 现型中不对称的流行率和影响仍然不清楚.
研究的目的:
- 研究神经成像不对称性在早期发病的阿尔茨海默病 (EOAD) 的患病率和临床相关性.
- 探索异构的EOAD介绍中不对称模式和特定认知缺陷之间的关系.
主要方法:
- 分析了来自373名粉胺-PET阳性EOAD患者 (MCI或轻度痴呆症) 的PET (florbetaben,flortaucipir) 和MRI数据.
- 使用Freesurfer细分计算了全球和voxelwise不对称指数.
- 与临床表型 (记忆录/非记忆录EOAD,PPA,PCA) 和认知表现相关的成像不对称性.
主要成果:
- 在成像模式中观察到全球不对称性,特别是在flortaucipir tau PET.
- 不对称性模式因临床表型而异 (例如,在PPA中左侧化,在PCA中右侧化).
- 佛罗西皮尔不对称性与较差的认知表现密切相关,特别是语言流性,工作记忆和视觉空间回忆.
结论:
- 非对称的神经成像在EOAD中普遍存在,并与临床表现相关.
- 特定的不对称性模式可以预测各种EOAD亚型的早期认知缺陷.
- 神经成像不对称性为预测早期阿尔茨海默病的认知表现提供了潜力.
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