基础科学和病原发生学
Mark He1, Sean R Jacobson2, Rebecca A Betensky3
1New York University (NYU) Grossman School of Medicine, New York City, NY, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
较高的中性粒细胞与淋巴细胞比率 (NLR),一种炎症标志物,与阿尔茨海默病和相关痴呆症 (AD/ADRD) 的风险增加有关. 这一发现基于一项大型电子健康记录研究,强调了外周炎症在ADRD发展中的重要性.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 老年学是指老年学的学科.
背景情况:
- 中性粒细胞与阿尔茨海默病 (AD) 病理学有关.
- 中性粒细胞与淋巴细胞的比率 (NLR) 表明中性粒细胞介导的炎症,并与痴呆风险有关.
- 之前关于NLR和痴呆风险的研究使用了小队列.
研究的目的:
- 在大量人群中调查NLR与痴呆风险之间的关联的概括性.
- 利用电子健康记录 (EHR) 数据进行全面分析.
主要方法:
- 分析了287985名患者 (2011-2023) 的电子病历数据.
- 使用因果特异性考克斯回归来评估NLR与AD/ADRD发病率之间的关联.
- 根据人口和临床混因素进行调整,死亡作为审查事件.
- 员工累积发病率函数 (CIF) 曲线用于随时间的风险评估.
主要成果:
- 在日志转换的NLR和ADRD风险之间发现了积极和独立的关联 (HR = 1.160).
- 观察到NLR和AD/ADRD风险之间显著增加的关系.
- 亚组分析证实了显著的关联,特别是西班牙裔患者的风险更高.
结论:
- 升高的NLR与未来AD/ADRD的风险增加有关.
- 这些发现强调了外周炎症在阿尔茨海默病理学中的作用.
- 需要进一步的研究来阐明将中性粒细胞生物学与AD联系起来的机制.
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