Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Infection01:20

Infection

11.6K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
11.6K
Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

524
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
524
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

676
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
676
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

2.5K
The pathophysiology of pneumonia involves the following steps:
2.5K
Stages of Infection01:26

Stages of Infection

64.7K
Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
64.7K
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

2.6K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
2.6K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

A Genome-wide Association Study of Alzheimer's Disease and Dementia in a Large Multi-ancestry Military Cohort Identifies Many New Dementia-Associated Loci.

medRxiv : the preprint server for health sciences·2026
Same author

Understanding Non-Attendance in Pediatric Otolaryngology: A Retrospective Study of Demographics, Socioeconomics, and Pandemic Effects.

The Annals of otology, rhinology, and laryngology·2025
Same author

Association between PM<sub>2.5</sub> air pollution and social deprivation in Western Pennsylvania.

Environmental epidemiology (Philadelphia, Pa.)·2025
Same author

Barriers to recruitment of an observational SARS-CoV-2 emergency department cohort at Boston Medical Center.

BMC emergency medicine·2025
Same author

The Impact of COVID-19 and Socioeconomic Determinants on Appointment Non-Attendance in an Urban Otolaryngology Clinic: A Retrospective Analysis From a Safety Net Hospital.

The Annals of otology, rhinology, and laryngology·2024
Same author

Genomic structural equation modeling reveals latent phenotypes in the human cortex with distinct genetic architecture.

Translational psychiatry·2024
Same journal

Unveiling the procoagulant state in Alzheimer's disease: A novel PET imaging strategy.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Estimated labor market outcomes of people progressing from preclinical to early-stage Alzheimer's disease in the United States.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Amyloid exacerbates tau and alpha-synuclein pathologies, behavioral impairments, and neuroinflammation in a mixed dementia model.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Multimorbidity burden and patterns associated with DeepBrainNet-derived brain-age gap in dementia-free older adults: A community-based study.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Reply to "Shifting the emphasis of brain health literacy from individuals to systems to reduce inequalities".

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Shifting the emphasis of brain health literacy from individuals to systems to reduce inequalities.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
查看所有相关文章

相关实验视频

Updated: Jan 7, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
09:07

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

Published on: June 14, 2020

11.5K

基础科学和病原发生学

Richard Sherva1,2, Henry Bayly3, Rui Zhang2

  • 1Biomedical Genetics, Department of Medicine, Boston University Medical School, Boston, MA, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
PubMed
概括
此摘要是机器生成的。

这项研究使用百万退伍军人计划在不同人群中确定了新型痴呆风险基因. 这些发现突出了参与神经元发育和一般痴呆途径的基因,推动了对痴呆症的遗传理解.

更多相关视频

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia
13:45

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia

Published on: September 21, 2019

6.0K
Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
08:38

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

6.3K

相关实验视频

Last Updated: Jan 7, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
09:07

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

Published on: June 14, 2020

11.5K
A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia
13:45

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia

Published on: September 21, 2019

6.0K
Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
08:38

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

6.3K

科学领域:

  • 遗传学 遗传学 是一个
  • 神经科学是一个神经科学.
  • 人口健康 人口健康

背景情况:

  • 越来越多的生物库队伍增加了痴呆症病例的基因元分析,识别了更多的风险变体.
  • 大多数痴呆症遗传研究缺乏多样性,非欧洲祖先的参与者数量少得多.
  • 百万退伍军人计划 (MVP) 提供了一个独特的队列,包括欧洲 (EUR),非洲 (AFR) 和西班牙裔 (HIS) 血统的参与者.

研究的目的:

  • 在MVP队列中分析三个痴呆症表型.
  • 将MVP痴呆症数据与现有的公共总结统计数据进行元分析.
  • 在不同祖先群体中识别新的痴呆风险变异.

主要方法:

  • 在MVP中分析了阿尔茨海默病和相关痴呆症 (ADRD),痴呆症药物处方和代理报告的痴呆症.
  • 在MVP祖先群体 (EUR,AFR,HIS) 中进行全基因组关联研究 (GWAS).
  • 结合MVP数据与公共统计数据的生成元分析 (Bellenguez等. 2022, 昆克尔等人 Kunkle等人. 2021) 用于欧元和交叉祖先分析.

主要成果:

  • 在EUR中确定了19个全基因组显著的新型区域 (GWS),在MVP EUR中确定了5个,在元分析中确定了14个.
  • 在跨祖先元分析中发现了11个新区域.
  • 发现了两个独特的AFR和HIS队伍的基因 (PAX7,PTPRD),以前只在HIS中观察到.

结论:

  • 特定于MVP的基因可能会影响一般性痴呆途径或具有性别特异性影响 (男性更强).
  • 来自EUR和交叉祖先分析的新基因与神经元发育,功能和认知结果有关.
  • 这项研究增强了对不同祖先痴呆症遗传学的理解.