痴呆症护理研究和心理社会因素
Christina M Magana-Ramirez1, Megan G Witbracht1,2, Crystal M Glover1,3
1University of California, Irvine, Irvine, CA, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
在愿意参与阿尔茨海默病 (AD) 生物标志物研究方面存在种族和民族差异. 与非西班牙裔白人参与者相比,代表性不足的群体对临床前AD试验的意愿较低.
科学领域:
- 神经科学是一个神经科学.
- 临床研究 临床研究
- 健康差异 在健康上的差异
背景情况:
- 阿尔茨海默病 (AD) 研究,特别是临床试验,缺乏多元化的社区代表.
- 临床前阿尔茨海默症试验要求认知能力正常的个体接受并理解生物标志物测试结果.
研究的目的:
- 调查在接受粉样蛋白PET扫描和学习结果的意愿方面的种族和种族差异.
- 特别是在临床前阿尔茨海默病试验的背景下评估愿意.
主要方法:
- 一项涉及257名参与者的研究按种族分组:西班牙裔/拉丁裔,非西班牙裔 (NH) 亚洲人,NH黑人和NH白人.
- 后勤回归分析被用来比较跨群体和背景的意愿,控制混因素.
主要成果:
- 对于粉样蛋白PET扫描和学习结果的整体意愿在种族和族群之间有显著差异 (p=0.034).
- 在临床前AD试验中接受生物标志物测试的意愿也因组而异 (p=0.005).
- 与NH White参与者相比,代表性不足的群体表现出不愿意接受试验生物标志物测试的可能性更高 (p<0.001).
结论:
- 种族和族裔与愿意接受生物标志物测试并收到结果的意愿有很大关系.
- 这些发现突出了阿尔茨海默病临床研究中多样性的潜在障碍,需要进一步调查.
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