生物标志物 生物标志物
Colleen Pappas1, Christopher E Bauer1, Valentinos Zachariou1
1University of Kentucky, Lexington, KY, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
血脑屏障 (BBB) 水交换率 (kw) 的增加与老年人随着时间的推移恶化的白质超强度 (WMHs) 有关. 这表明BBB功能障碍可能会导致脑血管疾病的进展.
科学领域:
- 神经成像是一种神经成像.
- 脑血管疾病研究研究
- 认知障碍研究 认知障碍研究
背景情况:
- 脑血管疾病 (CVD) 影响认知功能,导致认知障碍和痴呆症 (VCID).
- 血脑屏障 (BBB) 完整性越来越被认为是心血管疾病的一个因素.
- 磁共振成像 (MRI) 标志物,如白质超强度 (WMHs) 和自由水 (FW) 是已知的心血管疾病指标.
研究的目的:
- 为了研究BBB水交换率 (kw),BBB功能的衡量标准,以及大约2.5年的WMH和FW变化之间的关系.
- 探索基线BBB功能如何与脑血管损伤标志物的进展有关.
主要方法:
- 68名老年人使用扩散准备的伪连续动脉旋转标记 (DP-pCASL) 进行神经成像,以测量BBB水交换率 (kw),脑血流量 (CBF) 和动脉传输时间 (ATT).
- 在基线和随访时使用MRI (FLAIR和扩散权重成像) 量化WMH体积和白质FW.
- 混合效应模型分析了基线DP-pCASL测量和WMH或FW变化之间的关联,控制年龄,性别和内体积.
主要成果:
- 较高的基线BBB水交换率 (kw) 预测了随着时间的推移WMH的增加,尽管在基线上没有关系.
- 较高的基线脑血流 (CBF) 与基线较少的WMH相关,但与纵向变化无关.
- 动脉传输时间 (ATT) 与WMHs没有显著的关联.
- 较高的kw与较低的FW截面相关,但这在纵向上没有持续.
- 在基线或随着时间的推移,CBF和ATT与FW无关.
结论:
- 初步发现表明BBB的水交换率 (kw) 与WMH和基线FW的纵向变化有关.
- 在BBB中增加的水交换可能会增加对白质损伤的易感性.
- 需要进一步的研究,以充分阐明BBB效率对脑血管健康的影响.
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